CD23, also known as Fc epsilon RII, or FcεRII, is the "low-affinity" receptor for IgE, an antibody isotype involved in allergy and resistance to parasites, and is important in regulation of IgE levels. Unlike many of the antibody receptors, CD23 is a C-type lectin.

The CD23 molecule was discovered independently as an IgE receptor on human lymphoblastoid B cells [1], as a cell surface marker expressed on Epstein-Barr-Virus-transformed B cells (EBVCS) [2] and as a B-cell activation antigen (Blast 2) [3].

Here, we focus on CD23 and discuss several mechanisms related to IgE binding, as well as the impact of the IgE/antigen‐binding on different immune cells expressing CD23. One recent paper has shown that free IgE preferentially binds to FcεRI whereas IgE‐ICs are …

CD23 is a 45-kD type II membrane protein expressed in various cell types, including B cells. It is unique among Fc receptors in its homology to C-type (calcium-dependent) lectins (1) and is also closely homologous, and genetically linked on human chromosome 19, to DC-SIGN (3). IgE and CD21 are known to bind to this lectin domain (4).

Feb 7, 2024 · Here, we describe, in human pediatric peanut allergy, a population of CD23 + IgG1 + memory B cells arising in type 2 immune responses that contain high-affinity peanut-specific clones and generate IgE-producing cells upon activation.

In the present study we show that the CD23 R62W SNP is functionally relevant and leads to the up-regulation of IL-4 receptor expression on human B cells, and that SNPs involving substitutions of thymine for cytosine (C→T) can cause amino-acid exchanges of R-W in the coding regions of many other genes.

May 21, 2024 · CD23 mediates antimycobacterial activity of human macrophages (Infect Immun 2009;77:5537) Polymorphisms are associated with atopy, increased risk of exacerbations in patients with asthma and high serum IgE levels ( Am J Respir Cell Mol Biol 2014;50:263 )

May 16, 2016 · We found that in addition to marginal zone B cells, mature follicular B cells significantly down regulate the surface expression level of CD23 after undergoing isotype switch and memory B-cell...

Apr 1, 2012 · The anti-CD23 mAb lumiliximab downregulates IgE synthesis by human B cells in vitro and reduced human serum IgE levels in a phase I clinical trial in patients with mild to moderate persistent allergic asthma (10, 11). This provides proof of principle that mCD23 is a valid target for therapy.

Sep 19, 2005 · The low-affinity immunoglobulin E (IgE) receptor, CD23 (FcepsilonRII), binds both IgE and CD21 and, through these interactions, regulates the synthesis of IgE, the antibody isotype that mediates the allergic response.