We show using a direct RT‐PCR method for antigen‐specific VH, that FACS‐sorted mouse CD21 int CD23 + B cells express specific secretory IgM VH transcripts in response to immunization and also exhibit a memory response.

CD23, also known as Fc epsilon RII, or FcεRII, is the "low-affinity" receptor for IgE, an antibody isotype involved in allergy and resistance to parasites, and is important in regulation of IgE levels. Unlike many of the antibody receptors, CD23 is a C-type lectin.

Feb 1, 2002 · Transitional immature B cells undergo apoptosis and fail to proliferate in response to BCR cross-linking, thus representing a target for negative selection of potentially autoreactive B cells in vivo.

May 21, 2024 · Differentiates small lymphocytic lymphoma (SLL) / chronic lymphocytic leukemia (CLL) (CD23+) from mantle cell lymphoma or MALT lymphoma (CD23-) B cell marker, particularly for SLL / CLL, mediastinal large B cell lymphoma, lymphoplasmacytic lymphoma and diffuse follicular lymphoma ( Mod Pathol 2012;25:1637 , Blood Adv 2020;4:5652 )

Apr 15, 2006 · FDCs in mice immunized using Th1-polarizing CFA exhibit high levels of CD23, whereas little CD23 is detectable on FDCs from mice infected with the Th2-polarizing Nippostrongylus brasiliensis . These results prompted the hypothesis that T cells and associated lymphokines regulate FDC-CD23.

The structure of CD23 and the trimer model, the location of its binding sites for IgE and CD21, and the clustering of CD23 caused by IgE Fc lend support to this mechanism and suggest strategies for down-regulation of IgE levels to treat allergic disease.

Jul 14, 2015 · We assessed CD23 expression and its stabilization by FACS and used an ELISA for detecting soluble CD23. IgE synthesis was measured by ELISA and real‐time PCR. Surface plasmon resonance revealed affinities of the DARPins to CD23 in the pico‐molar range.

The low affinity IgE receptor, Fc∊RII (CD23), is both a positive and negative regulator of IgE synthesis. The proteinase activity that converts the membrane-bound form of CD23 into a soluble species (sCD23) is an important regulator of the function ...

Mar 4, 2021 · We discovered 2 mechanisms that drive human terminal B-cell differentiation. First, after an initial response to interleukin-4 (IL-4), cells that were committed to an ASC fate downregulated the CD23 marker and IL-4 signaling, whereas cells that maintained IL-4 signaling did not differentiate.

May 20, 2005 · Upregulation of CD23 by IL-4, GM-CSF and IL-4/GM-CSF. Alpha-smooth muscle isoactin positive Human ASMC (Clonetics) in T-75 flasks were starved for 24 h in 0.1% FBS containing medium M199. The cells were then stimulated with IL …