CD23, also known as Fc epsilon RII, or FcεRII, is the "low-affinity" receptor for IgE, an antibody isotype involved in allergy and resistance to parasites, and is important in regulation of IgE levels.

May 21, 2024 · CD23 is a low affinity immunoglobulin E (IgE) receptor Found on mature B cells, activated macrophages, eosinophils, follicular dendritic cells (FDCs), platelets and megakaryocytes (Sci Rep 2016;6:25629, Immunol Res 1992;11:252, World J Surg Oncol 2019;17:115, Eur J Immunol 1997;27:2212)

This review summarizes recent data on CD23, a low affinity receptor for IgE (Fc epsilon RII). CD23 is the only FcR which does not belong to the immunoglobulin gene superfamily.

Dec 6, 2014 · The CD23 protein can be cleaved and released into the serum as a soluble form of CD23 (sCD23). The sCD23 is a 25kDa fragment that can be found in serum, plasma and urine in patients with chronic lymphocytic leukemia.

CD23 has been proposed to participate in both a positive and a negative feedback mechanism in the regulation of IgE synthesis by B cells (3, 4). Human B cells undergo isotype class switching and begin to secrete IgE when stimulated with IL-4 plus anti-CD40.

While evidence from experimental disease models as well as allergic patient studies on CD23 is still lacking, evidence shows that i) CD23 can absorb and clear IgE from the serum in a non‐inflammatory fashion, ii) CD23 reduces the synthesis of IgE from B cells, iii) CD23 regulates antigen‐specific IgG and T cell responses.

The low affinity IgE receptor, Fc∊RII (CD23), is both a positive and negative regulator of IgE synthesis. The proteinase activity that converts the membrane-bound form of CD23 into a soluble species (sCD23) is an important regulator of the function ...

May 16, 2016 · We examined the expression of CD23 in different subsets of peripheral B cells and the impact of CD23 expression on the early events of B-cell receptor (BCR) activation using CD23 knockout...

CD23 is the low-affinity receptor for immunoglobulin (Ig)E and plays important roles in the regulation of IgE responses. CD23 can be cleaved from cell surfaces to yield a range of soluble CD23 (sCD23) proteins that have pleiotropic cytokine-like activities.

CD23 CD23 is the low-affinity receptor for IgE and is expressed on platelets, eosinophils, activated macrophages, follicular dendritic cells, and mature B cells. Though this antigen may be expressed on many B-cell lymphomas, its diagnostic utility is most helpful in separating small cell lymphocytic lymphoma from mantle cell lymphoma.