CD20 is a transmembrane protein consisting of four hydrophobic transmembrane domains, one intracellular domain and two extracellular loops. There are three different forms of CD20 according to variable phosphorylation. CD20 is located on the cell surface as homo-dimeric and homo-tetrameric oligomers.

Mar 26, 2025 · CD20 is a CD marker—a molecule on the cell surface that can be used to identify and type a particular cell in the body. CD20 is found on the surface of B cells (a type of immune system cell). But let's back up and make this easier to understand.

CD20 is a general B-cell marker expressed by the majority of B cells starting from late pre-B lymphocytes (it is not expressed by pro-B lymphocytes), and its expression is lost in terminally differentiated plasmablasts and plasma cells.

Mar 20, 2025 · CD20 is a protein found on the surface of certain immune cells, primarily B cells. It plays a key role in immune system function and is an important target in medical research and treatment, particularly in conditions affecting B cell activity …

Sep 20, 2021 · Which normal cell type is most associated with CD20 expression? CD20 is a common B cell marker also called L26, membrane spanning 4 domains (MS4A1).

This review summarises the latest understanding of CD20⁺ T cells, their presence in various diseases, their putative function and how they may be an ongoing target of CD20-depleting agents.

Feb 16, 2021 · Here, we demonstrate that CD20 controls the nanoscale organization of receptors on the surface of resting B lymphocytes. CRISPR/Cas9-mediated ablation of CD20 in resting B cells resulted in relocalization and interaction of the IgM-class B cell antigen receptor with the coreceptor CD19.

CD20 is a membrane-embedded surface molecule that is involved in the development and differentiation of B-cells into plasma cells. It is expressed on B-cells throughout their differentiation process until they become plasma cells.

Using CRISPR/Cas9 technique, we have abrogated CD20 expression in five different malignant B-cell lines. We show that CD20 deletion has no effect upon B-cell receptor signaling or calcium flux. Also B-cell survival and proliferation is unaffected in the absence of CD20.

CD20 was the first B cell differentiation antigen identified, and CD20-specific mAbs are commonly used for the treatment of B cell malignancies and autoantibody-mediated autoimmune diseases. Despite this the role of CD20 in human B cell physiology has remained elusive.