Jan 15, 2008 · As CD2 physically interacts with both Lck and Fyn, preferentially inside lipid rafts, and reflecting the increase of CD2 in lipid rafts following activation, CD2 can mediate the interaction between the two kinases and the consequent boost in kinase activity in lipid rafts.

Aug 5, 2022 · Using T cells from a CD2 knock-in mouse in which a tag was inserted at the carboxyl terminus of CD2, mass spectrometry analyses revealed that the role of CD2 in T cell activation correlated with its ability to interact with components of the TCR complex and the protein tyrosine kinase Lck.

Mar 1, 2008 · Protein interactions between CD2 and Lck are required for the lipid raft distribution of CD2. J. Immunol. 180: 988–997 . In the Abstract, the year and volume are incorrect in the print version and online PDF.

Lck has been shown to bind to CD2, CD5, CD44, CD48, CD55, CD146, and CD160 . These receptors are involved in several biological responses. CD2/LFA-3 is an interesting complex critical to immunological synapses, and CD2 is preferentially expressed in memory cells .

Jun 17, 2005 · Using a two color imaging approach that allows tracking of single molecules relative to the CD2/LAT/Lck clusters, we demonstrate that these microdomains exclude and limit the free diffusion of molecules in the membrane but also can trap and immobilize specific proteins.

Aug 1, 2015 · In this study, Lck and CD2 homologs were identified and characterized in channel catfish, Ictalurus punctatus. Lck and CD2 mRNAs were specifically expressed by clonal T cell lines, including both CD4 + and CD4 − CD8 − CTL lines, and in mixed lymphocyte cultures (MLC).

May 12, 2000 · Using JCaM1.6 cells, we have demonstrated that Lck is required for CD2-mediated phosphorylation of Dok proteins. We propose that phosphorylation and Src homology 2-mediated association of p56(dok) and p62(dok) with Lck play a selective function in accessory receptor signal transduction mechanisms.

Mar 1, 2008 · It is demonstrated that CD2 and p56lck associate when coexpressed in nonlymphoid cells, that this association requires the cytoplasmic domain of CD2, and that the SH3 domain of p56 lck mediates its interactions with CD2.

May 4, 2009 · Cytoplasmic domains of CD2 within highly concentrated microdomains, particularly poly proline regions, can activate Lck by competitively binding to autoinhibitory SH3 domain in Lck (inactive, closed form).

Feb 1, 2008 · Lck and CD2 mRNAs were specifically expressed by clonal T cell lines, including both CD4(+) and CD4(-)CD8(-) CTL lines, and in mixed lymphocyte cultures (MLC).