Jul 10, 2023 · Using patient-derived co-cultures, humanized mouse models, and single-cell RNA-sequencing of patient melanomas biopsied before and on immune checkpoint blockade, we …

CD58, lymphocyte-function antigen 3 (LFA-3), is a glycoprotein that plays a vital role in the body's immune response. The natural ligand to CD58, CD2, is most commonly found on the surfaces …

Jun 15, 2023 · We show that CD58 is crucial for infiltration of tumors by T cells, likely via its adhesive properties when ligated with CD2, and that increased CD58 co-stimulatory signaling …

May 19, 2022 · A preprint by Ho et al. investigates the role of decreased CD58 expression in cancer cell immune evasion, through both lack of T cell co-stimulation and increased T cell …

In particular, the CD2-CD58 interaction is involved in the regulation of antiviral responses, inflammatory responses in autoimmune diseases, immune rejection of transplantation, and …

Nov 5, 2024 · Evidence suggests the CD2:CD58 axis is crucial for the efficacy of chimeric antigen receptor (CAR) T cells. CD58 loss in cancer cells leads to CAR T cell resistance and CD2 …

Jul 15, 2015 · Blocking CD58 mAb greatly reduced the response of human CD28 (-)CD8 (+) T cells to allogeneic dendritic cells, as well as to viral Ags. Our results clearly identify the …

The CD58-CD2 axis regulates T cell-mediated cancer immunity, but little is known about the regulation of CD58. In two recent papers pubished in Cancer Cell, Miao et al. and Ho et al. …

Sep 14, 2020 · CD2–CD58 interactions in the corolla boosted signaling by 77% as compared with central CD2–CD58 interactions. Engaged PD-1 invaded the CD2 corolla and buffered CD2 …

Jun 8, 2021 · In particular, the CD2-CD58 interaction is involved in the regulation of antiviral responses, inflammatory responses in autoimmune diseases, immune rejection of …