Human CD19 (20-291), Fc Tag (CD9-H5259) is expressed from human 293 cells (HEK293). It contains AA Pro 20 - Lys 291 (Accession # P15391-1). This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 56.3 kDa.

CD19 activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca 2+ stores. CD19 polymorphisms are associated with the development of autoimmunity by promoting autoantibody production.

Recombinant human CD19 protein (Fc Chimera Active) is a protein, expressed in HEK 293, with >95% purity, 0.1 EU/µg endotoxin level and suitable for SDS-PAGE, Flow Cyt, FuncS.

Biotinylated Recombinant Human CD19 Fc Chimera binds to Human CD19 Antibody (Catalog # MAB4867) with an ED 50 of 25.0-250 ng/mL. Source Chinese Hamster Ovary cell line, CHO-derived human CD19 protein

CD19 protein is a 95 kDa transmembrane glycoprotein that plays a central role in B cell activation and humoral immune responses (1, 2). CD19 is expressed throughout B cell development from pre-B cells through mature B cells, and it is commonly used as a B cell lineage marker (1).

The CD19 protein is a B cell antigen receptor coreceptor that enhances downstream signaling pathways, lowers the activation threshold, and helps B cells respond to antigens. It activates phosphatidylinositol 3-kinase and mobilizes intracellular Ca(2+).

Jan 29, 2013 · We describe the studies for the development and evaluation of this fusion protein. The properties of this reagent make possible sensitive detection by flow cytometry of cells modified with CD19-specific CAR.

Apr 16, 2009 · The Fc-engineered anti-CD19 antibody, XmAb5574, has enhanced Fcgamma receptor (FcgammaR) binding affinity, leading to improved FcgammaR-dependent effector cell functions and antitumor activity in murine xenografts compared with the non-Fc-engineered anti-CD19 IgG1 analog.