CD19 is widely expressed during all phases of B cell development until terminal differentiation into plasma cells. During B cell lymphopoiesis, CD19 surface expression starts during immunoglobulin (Ig) gene rearrangement, which coincides during B …

CD19 protein appears early during B-cell maturation and is found during all stages of B-cell maturation, including plasma cells. CD19 is useful as an additional marker of B cell lineage in leukemias and lymphomas.

CD19 is a biomarker for normal and neoplastic B cells, as well as follicular dendritic cells. CD19 is critically involved in establishing intrinsic B cell signaling thresholds through modulating both B cell receptor-dependent and independent signaling.

Mar 18, 2025 · CD19 is a key marker on B cells, playing a crucial role in immune responses. When its expression is abnormally high, it can indicate immune system dysregulation. Identifying the causes of this elevation is essential for understanding potential health implications.

The largely B cell-restricted expression of two cell surface markers, CD19 and CD20, provides an opportunity to selectively target B cells with immunotherapeutic cytotoxic agents.

Jan 16, 2021 · CD19+ B cells, or B lymphocytes, are a type of immune cell derived from the common lymphoid progenitor in the bone marrow. B lymphocytes play a significant role in humoral immunity by producing antibodies which neutralize microorganisms and initiating signaling pathways for other immune cells.

Critical Role in B-Cell Development: CD19 is pivotal in the maturation of B-cells, aiding their growth and functionality. Therapeutic Target: Its unique expression patterns allow CD19 to be a prime target for therapies such as monoclonal antibodies and CAR T-cell treatments.

In this review we will describe the main subsets of B cells in peripheral blood and how these can be identified using flow and mass cytometry, as well as important changes in B-cell subsets in inflammatory immune mediated conditions.

CD19 is a critical marker and functional component of B-cells, playing a significant role in the immune response. Its presence on B-cells is leveraged in both diagnostic and therapeutic contexts to manage and treat various immune-related conditions and cancers.

Dec 2, 2007 · CD19 is a B cell–specific coreceptor expressed at early stages of B cell development. It has been shown to enhance signaling through the BCR. In the plasma membrane of B cells, CD19 is...