Signaling lymphocytic activation molecule 1 is a protein that in humans is encoded by the SLAMF1 gene. [5][6] Recently SLAMF1 has also been designated CD150 (cluster of differentiation 150). SLAMF1 belongs to the signaling lymphocytic activation molecule family.

The extracellular domain of CD150 is the receptor for measles virus and CD150 acts as a co-activator on T and B cells. We characterized the mouse and human CD150 genes, each of which comprises seven exons spanning approximately 32 kb.

Jan 1, 2003 · Measles virus uses CD150 as a receptor and Molluscum contagiosum virus encodes proteins that are homologous to CD150. Thus, viruses use CD150 subfamily receptors to create a favorable...

CD150 (SLAM) family receptors have recently been shown to be differentially expressed by mouse HSC and progenitor cells. Members of the CD150 family are key regulators of leukocyte activation and differentiation.

SLAMF1/CD150 receptor is a founder of signaling lymphocyte activation molecule (SLAM) family of cell-surface receptors. Initially, CD150 was identified as a marker of activated B cells by monoclonal antibody (mAb) IPO-3 [1, 2].

Jul 1, 2019 · CD150 expression on neoplastic cells in hematologic malignancies is distinct from their normal analogues. CD150 mediates signaling in normal and malignant hematopoietic cells. CD150 is a potential target for therapeutic intervention in leukemias and lymphomas.

Mar 1, 2018 · Here, we describe a Treg subpopulation that controls hematopoietic stem cell (HSC) quiescence and engraftment. These Tregs highly expressed an HSC marker, CD150, and localized within the HSC niche in the bone marrow (BM). Specific reduction of BM Tregs achieved by conditional deletion of CXCR4 in Tregs increased HSC numbers in the BM.

Here, we describe a Treg subpopulation that controls hematopoietic stem cell (HSC) quiescence and engraftment. These Tregs highly expressed an HSC marker, CD150, and localized within the HSC niche in the bone marrow (BM). Specific reduction of BM Tregs achieved by conditional deletion of CXCR4 in Tregs increased HSC numbers in the BM.

Feb 24, 2015 · CD150 (IPO3/SLAM, for Signaling Lymphocytic Activation Molecule) is a membrane protein that belongs to the SLAM family within the immunoglobulin superfamily of surface receptors. In humans it is encoded by the SLAMF1 gene [ 1 – 3 ].

Due to CD150 signaling properties it is involved in regulation of malignant cell fate decision and tumor microenvironment in Hodgkin's lymphoma and chronic lymphocytic leukemia. This review summarizes evidence for the important role of CD150 in …