- CD14 is a co-receptor of Toll-like receptor (TLR)− 4, with a critical role in innate immune responses. CD14 recognizes bacterial lipopolysaccharides, pathogen-, and damage-associated molecular patterns, thereby facilitating inflammatory immune responses.www.sciencedirect.com/science/article/pii/S1359610123000552
CD14 controls the LPS-induced endocytosis of Toll-like …
Using this assay, we determined if CD14 regulates TLR4 transport as a means of controlling IFN production. LPS-induced TLR4 endocytosis was examined in BMDM and immature dendritic cells (DCs) from wild type (WT) and CD14 …
TLR4 and CD14 trafficking and its influence on LPS-induced pro ...
In this review, we focus on the mechanisms of the internalization and intracellular trafficking of TLR4 and CD14, and also of LPS, in immune cells and discuss how dysregulation of the endo …
- Author: Anna Ciesielska, Marta Matyjek, Katarzyna Kwiatkowska
- Publish Year: 2021
Role of CD14 in human disease - PMC
The cell surface antigen CD14 is primarily understood to act as a co-receptor for toll-like receptors (TLRs) to activate innate immunity responses to pathogens and tissue injury in macrophages …
A TLR4-independent critical role for CD14 in …
May 3, 2022 · By generating Cd14−/− mice on a Tlr4 -deficient background, we reveal that CD14 plays an essential TLR4-independent role in caspase-11 activation in vivo by delivering LPS intracellularly. Thus, we demonstrate …
Multifaceted role of CD14 in innate immunity and tissue homeostasis
Dec 1, 2023 · CD14 is a co-receptor of Toll-like receptor (TLR)− 4, with a critical role in innate immune responses. CD14 recognizes bacterial lipopolysaccharides, pathogen-, and damage …
Therapeutic Boosting of the Immune Response: Turning to CD14 …
Efficient responses via TLRs require the activity of the co-receptor CD14, which enhances TLR responses. In an attempt to boost the immune response for therapeutic purposes, we have …
Targeting the TLR Co-Receptor CD14 with TLR2 …
May 15, 2013 · Biochemical, cell imaging, and molecular docking studies showed that peptide binding to CD14 accelerates microbial ligand transfer from CD14 to TLR2, resulting in increased and sustained ligand occupancy of TLR2 and …
A TLR4-independent critical role for CD14 in intracellular LPS
May 3, 2022 · By generating Cd14 -/- and Casp11 -/- mice strains on a Tlr4 -/- background, we dissociate CD14's known role in TLR4 signaling from its role in caspase-11 activation and …
CD14 Controls the LPS-Induced Endocytosis of Toll-like …
Nov 11, 2011 · The pattern recognition receptor CD14 not only delivers bacterial lipopolysaccharide to TLR4 on the plasma membrane of dendritic cells but also regulates TLR4 endocytosis and trafficking to the endosomes to trigger …
