In this review, we will discuss known mechanisms underlying the therapeutic efficiency of CD14, TLR4, and CD11b/CD18 antibodies with a focus on LPS-dependent ROS or cytokine production by PMNs or monocytes.

Our findings in this study indicate that Group 1 monocytes are a subpopulation of CD14 + CD16 + monocytes that produce more ROS and inflammatory mediators, suggesting that entry of these cells into the CNS would contribute significantly to HIV …

Sep 22, 2011 · Gene Ontology (GO) enrichment analysis suggests diverse immunologic functions, linking CD14 ++ CD16 + monocytes to Ag processing and presentation (eg, CD74, HLA-DR, IFI30, CTSB), to inflammation and monocyte activation (eg, TGFB1, AIF1, PTPN6), and to angiogenesis (eg, TIE2, CD105).

Mar 3, 2019 · We believe that blockade of CD14 on the cell surface and clinical use of anti-CD14 mAbs or their Fab fragments may diminish the production of ROS and improve outcomes during cardiovascular diseases manifested by LPS-induced inflammation.

Nov 4, 2010 · In this study, we report a difference in apoptotic potential between these two subsets with CD14 +/low CD16 + monocytes being more susceptible than CD14 + CD16 − monocytes to undergo...

Nov 4, 2010 · In this study, we report a difference in apoptotic potential between these two subsets with CD14 +/low CD16 + monocytes being more susceptible than CD14 + CD16 − monocytes to undergo spontaneous apoptosis and apoptosis induced by …

Nov 20, 2020 · In this review, we will discuss known mechanisms underlying the therapeutic efficiency of CD14, TLR4, and CD11b/CD18 antibodies with a focus on LPS-dependent ROS or cytokine production by PMNs or monocytes.

In this review, we will discuss known mechanisms underlying the therapeutic efficiency of CD14, TLR4, and CD11b/CD18 antibodies with a focus on LPS-dependent ROS or cytokine production by PMNs or monocytes.

Sep 9, 2009 · CD14, TLR4, and TLR2 function along with CD36, the α 6 β 1 integrin, and CD47 as members of the fAβ receptor complex whose engagement initiates the parallel signaling cascades of Src-Vav-Rac and the p38 MAP kinase for the induction of ROS, phagocytosis, and NFκB activation.

Sep 24, 2010 · Human CD14 + monocytes specialize in phagocytosis and production of reactive oxygen species and secrete inflammatory cytokines in response to a broad range of microbial cues. Here, we have characterized the functions of human monocytes that lack CD14 (CD14 dim) and express CD16.