Human dendritic cell subsets - PMC - PubMed Central (PMC)
Myeloid DCs (mDCs) express typical myeloid antigens CD11c, CD13, CD33 and CD11b, corresponding to mouse CD11c + ‘classical’ or ‘conventional’ DCs. In humans both monocytes …
CD14 is expressed by subsets of murine dendritic cells and ... - PubMed
The CD14 surface molecule is predominantly expressed by cells of myeloid origin and regarded as a specific marker for macrophages (M phi). Thus, in human mononuclear cell preparations, …
Human dendritic cell subsets: an update - PMC - PubMed Central …
Detailed phenotyping and single‐cell gene expression studies have recently characterized two subsets of cDC2 in human blood, one ‘DC‐like’ with higher expression of CD5, CD1c, HLA‐DQ …
CD14 - Wikipedia
CD14 exists in two forms, one anchored to the membrane by a glycosylphosphatidylinositol (GPI) tail (mCD14), the other a soluble form (sCD14). Soluble CD14 either appears after shedding of …
Human peripheral blood dendritic cells and monocyte subsets …
Three major CD33(+) subsets including CD33(bright)CD14(bright) Mo, CD33(bright)CD14(-) CD11c(+) mDC and CD33(dim)CD14(-) pDC were present. Dendritic cells subsets and Mo …
Role of CD14 in human disease - PMC - PubMed Central (PMC)
The cell surface antigen CD14 is primarily understood to act as a co-receptor for toll-like receptors (TLRs) to activate innate immunity responses to pathogens and tissue injury in macrophages …
Expression of CD14, IL-10 and tolerogenic signature in dendritic …
Jul 7, 2017 · The differential expression of CD14 and IL-10 was confirmed at the proteomic level and observed that MCP-1 and MDC protein levels correlated (directly or inversely, …
Characterization of human blood dendritic cell subsets
Dec 15, 2002 · However, recent evidence suggests that one or more DC or DC-like populations may express CD14, CD2, or CD16, which have traditionally been associated with Lin + cells. 5 …
Cancer Vaccines in the World of Immune Suppressive Monocytes (CD14
Apr 4, 2014 · To generate mDC in vitro for clinical use, the CD14 + monocytes are the preferred precursor due to their abundance and ease of collection. CD14 + monocytes are purified from …
Clinical-grade manufacturing of DC from CD14
We evaluated a clinical-grade protocol for the manufacture of mature DC from CD14 + precursors derived from normal donors and patients suffering from CML and stage IV malignant …