- The CD14 gene is located at bands 5q23-q31, encoding 1400 bp RNA. After the translation, the C-terminal guide sequence (28–32 amino acids) was replaced by glycosylposphatidylinositol (GPI) anchor. Therefore, membrane-bound forms of CD14 (mCD14) is anchored on the surface of cell membrane by GPI tail.Learn more:The CD14 gene is located at bands 5q23-q31, encoding 1400 bp RNA. After the translation, the C-terminal guide sequence (28–32 amino acids) was replaced by glycosylposphatidylinositol (GPI) anchor. Therefore, membrane-bound forms of CD14 (mCD14) is anchored on the surface of cell membrane by GPI tail.www.sciencedirect.com/science/article/pii/S135961…CD14 exists in two forms, one anchored to the membrane by a glycosylphosphatidylinositol (GPI) tail (mCD14), the other a soluble form (sCD14). Soluble CD14 either appears after shedding of mCD14 (48 kDa) or is directly secreted from intracellular vesicles (56 kDa). [7]en.wikipedia.org/wiki/CD14CD14 is a 55 kDa glycoprotein found as a glycosyl phosphatidylinositol (GPI)-anchored species on monocytes, macrophages and as an abundant protein in plasma.www.sciencedirect.com/topics/neuroscience/cd14
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See all on WikipediaCD14 - Wikipedia
CD14 exists in two forms, one anchored to the membrane by a glycosylphosphatidylinositol (GPI) tail (mCD14), the other a soluble form (sCD14). Soluble CD14 either appears after shedding of mCD14 (48 kDa) or is directly secreted from intracellular vesicles (56 kDa). See more
CD14 (cluster of differentiation 14) is a human protein made mostly by macrophages as part of the innate immune system. It helps to detect bacteria in the body by binding lipopolysaccharide (LPS), a See more
CD14 is expressed mainly by macrophages and (at 10-times lesser extent) by neutrophils. It is also expressed by dendritic cells. The soluble form of the receptor (sCD14) is … See more
CD14 acts as a co-receptor (along with the Toll-like receptor TLR 4 and MD-2) for the detection of bacterial lipopolysaccharide (LPS). CD14 can bind LPS only in the presence of lipopolysaccharide-binding protein (LBP). Although LPS is considered its main See more
CD14+ monocytes can differentiate into a host of different cells, including dendritic cells, a differentiation pathway encouraged by See more
Wikipedia text under CC-BY-SA license Role of CD14 in host protection against infections and …
CD14 is a glycosylphosphatidylinositol (GPI)-anchored receptor known to serve as a co-receptor for several Toll-like Receptors (TLRs) both at the cell surface and in the endosomal compartment.
Role of CD14 in human disease - PMC
CD14 is biologically active as either a monomeric protein [17] attached to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor (mCD14) or as a secreted soluble protein (sCD14) …
CD14: Biology and role in the pathogenesis of disease
Aug 1, 2019 · The CD14 gene is located at bands 5q23-q31, encoding 1400 bp RNA. After the translation, the C-terminal guide sequence (28–32 amino acids) was replaced by …
- Author: Zhenghao Wu, Zhenxiong Zhang, Zehua Lei, Ping Lei
- Publish Year: 2019
Cell Activation Mediated by Glycosylphosphatidylinositol …
CD14 is a glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein which functions as a receptor on myeloid cells for ligands derived from microbial pathogens such as …
Role of CD14 in host protection against infections and in
Jul 24, 2013 · CD14 is a glycosylphosphatidylinositol (GPI)-anchored receptor known to serve as a co-receptor for several Toll-like Receptors (TLRs) both at the cell surface and in the …
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Soluble CD14: genome-wide association analysis and relationship …
We identified two genome-wide significant sCD14-associated loci, the CD14 structural locus on chromosome 5q21 and a novel missense variant of PIGC, which encodes an enzyme required …
An examination of the LPS-TLR4 immune response through the …
Mar 18, 2025 · CD14 exists in two forms: a glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein and a soluble serum protein lacking the GPI tail, both capable of …
CD14 - PubMed
The GPI-anchored 55 kDa glycoprotein CD14 is expressed on monocytes/macrophages and to a lesser extent on granulocytes. Engagement of CD14 by ligands like lipopolysaccharide, intact …
CD14 - an overview | ScienceDirect Topics
The membrane-bound CD14 is a glycoprotein with a molecular weight of 53–55 kDa, attached to the cell membrane by a glycosylphosphatidylinositol (GPI) anchor. The sCD14 is generated …
