May 18, 2024 · Here, we investigated the proportion of CD11c + microglia in six CNS regions (forebrain, olfactory bulb, diencephalon/midbrain, cerebellum, pons/medulla, and spinal cord) from the developmental to adult stages by flow cytometry and immunohistochemical analyses using a CD11c reporter transgenic mouse line, Itgax-Venus.

May 18, 2024 · Here, we investigated the proportion of CD11c + microglia in six CNS regions (forebrain, olfactory bulb, diencephalon/midbrain, cerebellum, pons/medulla, and spinal cord) from the developmental to adult stages by flow cytometry and immunohistochemical analyses using a CD11c reporter transgenic mouse line, Itgax-Venus.

Nov 20, 2023 · Using a brain-first mouse model of PD, we demonstrate αSyn trafficking from the brain to the ileum of male mice. Immunohistochemistry revealed that the ileal αSyn aggregations are contained...

May 18, 2024 · Here, we investigated the proportion of CD11c + microglia in six CNS regions (forebrain, olfactory bulb, diencephalon/midbrain, cerebellum, pons/medulla, and spinal cord) from the developmental to adult stages by flow cytometry and immunohistochemical analyses using a CD11c reporter transgenic mouse line, Itgax-Venus.

Using mice transcribing the green fluorescent protein under the promoter of the DC marker CD11c (itgax), we identified a juxtavascular population of cells expressing this DC marker and demonstrated their origin from bone marrow and local microglia.

CD11c + microglia enriched for osteopontin (OPN) expression appear at distinct stages of brain development, aging, and several neurodegenerative disorders. Whether coexpression of CD11c and OPN results from microglial activation or represents a part of a subset-specific genetic program is unknown.

Single-cell RNA sequencing α (scRNA-seq) revealed that the brain and ileum share a distinctive subpopulation of CD11c+ microglia-like cells that become activated in PD animals, in addition to a...

Feb 24, 2023 · Studies in the developing mouse brain demonstrated that partial depletion of IGF-1 in CD11c + microglia led to a reduction in brain weight, decrease in PLP, MBP, MAG, and MOG expression,...

Nov 20, 2023 · Using a brain-first mouse model of PD, we demonstrate αSyn trafficking from the brain to the ileum of male mice. Immunohistochemistry revealed that the ileal αSyn aggregations are contained within CD11c + cells.

Jan 1, 2016 · Here, we investigate the role of CNS CD11c + cells by exploiting a transgenic mouse model, CD11c‐DTR/GFP (Jung et al, 2002), which uses the commonly accepted DC marker CD11c to specifically target DCs.