Expression of the integrins CD11a, CD11b, CD11c, and CD18 on neutrophils was markedly lower during the acute stages of all three malaria types than in blood samples from controls. The expression of all four integrins was higher in convalescence than during acute infection.

Apr 3, 2023 · The deficiency of CD11a, CD11b, or CD11d did not affect neutrophil maturation (supplemental Figure 6A-B), indicating that only CD11c affected neutrophil maturation among β2 integrins. Next, we sought to compare the functions of …

CD11c/CD18 (CD11c; also called αXβ2, complement receptor 4, p150,90; gene Itgax) is a member of leukocyte adhesion molecule β2 integrins. β2 integrins consist of 4 members CD11a/CD18 (CD11a, αLβ2, leukocyte function-associated antigen-1; gene Itgal), CD11b/CD18 (CD11b, αMβ2, macrophage-1 antigen; gene Itgam), CD11c, and CD11d/CD18 ...

Mar 3, 2025 · Here we reviewed CD11c current state of art, in comparison to its sister proteins CD11a, CD11b, and CD11d, illustrating its unique feature in leukocyte biology. CD11c is largely known as a dendritic cell surface marker in immunology field (1).

In the present study, we examined the expression of CD11a, CD11b, and CD11c in the myocardial tissues of the rat using a Isoprenaline (ISO)-induced myocardial hypertrophy model. We also investigated the signal transduction mechanisms …

Feb 1, 2000 · The effects of increased stress on aggregates formed through CD11a/CD18 or CD11b/CD18 were examined by blocking each with antibody. Plots of peak aggregation versus shear stress indicated that either CD11a/CD18 or CD11b/CD18 can support adhesion at stresses less than 4 dyne/cm 2 (Figure 8A).

CD11a/CD18 are apparent on early progenitors of all myeloid and erythroid cells. CD11b/CD18 and CD11c/CD18 are more restricted antigens normally expressed on monocytes, macrophages, PMN and natural killer cells. Activated granulocytes and monocytes express far more CD11b/CD18 than the other two antigens:

CD11a is ubiquitously expressed on leukocytes and involved in a number of important functions in leukocytes, including trafficking and immunological synapse formation.5,6 CD11b is mainly expressed on innate immune cells and plays a role in their recruitment, phagocytosis, and cell death.7-10 In contrast to CD11a and CD11b, CD11c has been primari...

Dec 22, 2020 · This study shows that CD11c, a well-known dendritic cell marker, is expressed on HSPCs and serves as their functional regulator. CD11c deficiency leads to the loss of HSPCs via apoptosis in sepsis and bone marrow transplantation.

The function of the leukocyte integrin molecules (CD11a, CD11b, CD11c, CD18) and the Fc receptors (CD64, CD32, CD16) are at least partly understood. As well as being involved in intracellular adhesion, CD11b and CD11c function as complement receptors (CR3 and CR4 respectively) and CD35 is the CR1 receptor.