CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). Along with the TCR, the CD8 co-receptor plays a role in T cell …

CD8 deficiency is an extremely rare autosomal recessive disorder due to homozygous variants in the CD8A gene. CD8 is a T cell receptor (TCR) accessory molecule that interacts with the …

Resting naive CD8 + T cells have an astounding capacity to react to pathogens by massive expansion and differentiation into cytotoxic effector cells that migrate to all corners of the body …

Mar 20, 2025 · Explore the role of CD8 activation markers in T-cell function, their expression across tissues, and methods for assessing immune responses in different contexts. CD8 T …

Jan 15, 2025 · CD8 is a surface glycoprotein predominantly expressed on cytotoxic T-cells, a specialized subset of T-cells tasked with directly eliminating infected or malignant cells. Unlike …

Cytotoxic CD8 + T cells play a key role in the elimination of intracellular infections and malignant cells and can provide long-term protective immunity. In the response to infection, CD8 + T cell …

Nov 1, 2023 · CD8 T cells play crucial roles in immune surveillance and defense against infections and cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and …

T-cell surface glycoprotein CD8 alpha chain (C luster of D ifferentiation 8a), is a protein encoded by CD8A gene. [5] The CD8 protein is a cell surface glycoprotein found on most cytotoxic T …

In this review, we discuss the utility of CD8 in relation to its immunomodulatory properties. We outline the unique structure and function of different CD8 domains (ectodomain, hinge, …

Aug 24, 2023 · Both the CD8 antigen (acting as a coreceptor) and the T cell receptor recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC …