Complement receptor type 2 (CR2), also known as complement C3d receptor, Epstein–Barr virus receptor, and CD21 (cluster of differentiation 21), is a protein that in humans is encoded by the CR2 gene.

Aug 18, 2023 · Distinguish splenic littoral cell angioma (CD21+ lining cells) from splenic hamartomas (CD21-, Am J Surg Pathol 1997;21:827) Confirm that atypical cells have follicular dendritic origin in fine needle aspirates of hyaline-vascular …

Jan 21, 2010 · Here, we have identified 2 subsets of human transitional B cells based on the differential expression of CD21. CD21 hi transitional cells displayed higher expression of CD23, CD44, and IgD, and exhibited greater proliferation and Ig secretion in vitro than CD21 lo transitional B cells.

CD21-/low memory B cells are expanded with age in healthy individuals and in patients with viral infections and autoimmune conditions and are associated with pathogen-specific antibodies as well as key disease manifestations.

T-cell lines have also been reported to be resistant to EBV infection or susceptible (20, 21), but follow-up studies were not done. Recently, we reported that in contrast to the EBV-1 strain, the less common EBV type 2 strain (EBV-2) can latently infect primary mature CD3 + T cells in vitro with a higher frequency of CD8 + T cell infection than ...

Here, we show that CD21 –/low cells represent approximately 5% of B cells in peripheral blood from adults but are barely detectable in cord blood, after excluding transitional B cells.

Nov 4, 2010 · According to our data it seems more likely that CD21 low B cells of CVID patients are related to tissue-like memory B cells in tonsils of immunologically healthy individuals 5 and therefore resemble tissue associated innate-like B cells, which reveal partial anergy in vitro due to their “exhausted” preactivation state in vivo.

Jun 17, 2010 · Complement receptor 2–negative (CR2/CD21 −) B cells have been found enriched in patients with autoimmune diseases and in common variable immunodeficiency (CVID) patients who are prone to autoimmunity. However, the physiology …

Oct 21, 2020 · Human CD21 low B cells are expanded in autoimmune (AI) diseases and display a unique phenotype with high expression of co-stimulatory molecules, compatible with a potential role as antigen-presenting cells (APCs).

Mar 1, 2001 · CD21 is produced by B cells and follicular dendritic cells, where it binds cleavage products of the C3 complement protein. CD21 facilitates internalization of immune complexes by B cells to enhance antigen presentation.