CCR8-targeted specific depletion of clonally expanded Treg cells in ...
Feb 15, 2022 · Despite induction of such potent tumor immunity, anti-CCR8 mAb treatment elicited minimal autoimmunity in mice, contrasting with systemic Treg depletion, which …
The impact of CCR8+ regulatory T cells on cytotoxic T cell ... - Nature
Mar 30, 2022 · Recent studies identified selective CCR8 expression on tumor-infiltrating Tregs; CCR8+ Tregs have been indicated as a possible new target of cancer immunotherapy. Here, …
CCR8: a promising therapeutic target against tumor …
Jan 30, 2025 · Recent studies demonstrate that CC chemokine receptor (CCR)8 is highly and specifically expressed on effector TI-Treg cells in mice and humans, highlighting CCR8 as a promising target for selective TI-Treg cell depletion in …
- Studies of CCR8 Treg
A single-cell atlas reveals immune heterogeneity in anti-PD-1 …
Mar 26, 2025 · Cox proportional hazards model was used to calculate the hazard ratio between patient subgroups. The HR of PRR, proportion of Texp in Tex-relevant cells, and CCR8 + …
CCR8 marks highly suppressive Treg cells within …
High levels of expression of chemokine (C‐C motif) receptor 8 (CCR8) discriminate Treg cells within tumours from those found in systemic lymphoid tissues.
CCR8+FOXp3+ Treg cells as master drivers of immune …
May 22, 2017 · The current study identifies CCR8 + regulatory T cells (T reg cells) as drivers of immunosuppression. We show that in human peripheral blood cells, more than 30% of T reg up-regulate CCR8 following activation in the presence …
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Fc-Optimized Anti-CCR8 Antibody Depletes Regulatory T Cells in …
Jun 1, 2021 · Preclinical mouse tumor modeling showed that depletion of CCR8 + Tregs through an FcyR-engaging anti-CCR8 antibody, but not blockade, enabled dose-dependent, effective, …
Selective Depletion of CCR8+Treg Cells Enhances the Antitumor …
Mar 5, 2025 · Accumulation of regulatory T (Treg) cells, an immunosuppressive population, limits the efficacy of immunotherapy in NSCLC. C-C motif chemokine receptor 8 (CCR8) is …
Differential expression of CCR8 in tumors versus normal tissue …
We show that CCR8 gene expression is restricted to tumor resident Tregs, and that CCR8 protein is expressed at higher densities on tumor resident Tregs than on other tumor resident T cells …
Development of a CCR8 monoclonal antibody to block CCR8 …
May 31, 2023 · Tumor-associated Tregs express the chemokine receptor CCR8, which is involved in the induction, expansion, migration, and immunosuppression of Tregs, making targeted …
