Jul 15, 1998 · The CCR8 ligands I-309 and its mouse homologue T cell activation gene 3 (TCA-3) are potent chemoattractants for Th2-polarized cells. Taken together, these observations strongly suggest that CCR8 plays a role in the control of Th2 responses, and may represent a potential target for treatment of allergic diseases.

Nov 15, 2006 · CCR8 expression is primarily restricted to a subset of human CD4 memory T lymphocytes (15%). Approximately 40% of CCR8+CD4+ T cells express Th2 cytokines IL-4 or IL-13 while 13% express the Th1 cytokine IFN-gamma. In fact, 50% of all Th2, but only 5% of Th1, cells express CCR8.

We used adoptive transfer experiments to compare the trafficking of wild type antigen-specific Th2 cells with antigen-specific Th2 cells deficient in CCR4, CCR8 or CXCR3. CCR4-deficient antigen-specific Th2 cells failed to traffic efficiently into the lung and the airways.

Feb 1, 2025 · Recent studies demonstrate that CC chemokine receptor (CCR)8 is highly and specifically expressed on effector TI-Treg cells in mice and humans, highlighting CCR8 as a promising target for selective TI-Treg cell depletion in the treatment of various cancers.

Jul 15, 1998 · In this paper we report on the cloning and characterization of mouse CCR8. Like its human homologue, it is predominantly expressed in the thymus. In the periphery, murine CCR8 mRNA was found most abundantly expressed in activated Th2 …

CONCLUSIONS: We provide evidence that CCR8 mediated signaling promotes the specific migration and localization of Th2-inducing CD301b+ DCs, thereby controlling the induction of Th2 differentiation. These data reveal the CCR8 pathway as a …

Sep 18, 2018 · In CCR8-deficient mice, CD301b + DCs remained in the SCS and were unable to enter the LN parenchyma, resulting in defective Th2 differentiation. We have defined a CCR8-dependent stepwise mechanism of DC-subset-specific migration through which LN CD169 + SIGN-R1 + macrophages control the polarization of the adaptive immune response.

Feb 2, 2005 · CCR8 was initially described as a Th2 cell-restricted receptor, but this has not been fully tested in vivo. The present study used ex vivo and in vivo approaches to examine the distribution and functional significance of CCR8 among CD4 + T cells.

Jan 1, 2009 · We used adoptive transfer experiments to compare the trafficking of wild-type antigen-specific T H 2 cells with antigen-specific T H 2 cells deficient in CCR4, CCR8, or CXCR3. CCR4-deficient antigen-specific T H 2 cells failed to traffic efficiently into the lung and the airways.

Jul 15, 1998 · In this paper we report on the cloning and characterization of mouse CCR8. Like its human homologue, it is predominantly expressed in the thymus. In the periphery, murine CCR8 mRNA was found...