Differential expression of CCR8 in tumors versus …
CCR8 expression is highly restricted to tumor-infiltrating Tregs. To identify novel therapeutic targets that could enable specific depletion of tumor-infiltrating Treg cells, we conducted an in-silico screen using The Cancer Genome Atlas …
CCR8: a promising therapeutic target against tumor …
Jan 30, 2025 · Recent studies demonstrate that CC chemokine receptor (CCR)8 is highly and specifically expressed on effector TI-Treg cells in mice and humans, highlighting CCR8 as a promising target for selective TI-Treg cell depletion in …
CCR8 antagonist suppresses liver cancer progression via turning …
Apr 4, 2025 · CCR8 is highly expressed in tumor tissues of HCC patients and associated with poor prognosis. A The expression level of CCR8 in primary tumor tissues and normal tissue …
CCR8 as a Therapeutic Novel Target: Omics-Integrated …
This analysis will encompass the correlations between CCR8 subunit expression levels and tumor immune infiltration levels (B cells, CD4 T cells, CD8 T cells, neutrophils, macrophages, and …
The impact of CCR8+ regulatory T cells on cytotoxic T cell ... - Nature
Mar 30, 2022 · Recent studies identified selective CCR8 expression on tumor-infiltrating Tregs; CCR8+ Tregs have been indicated as a possible new target of cancer immunotherapy. Here, …
Targeting tumor-infiltrating CCR8 - BioMed Central
Jul 30, 2024 · Chemokine (C-C motif) receptor 8 (CCR8) is a chemokine receptor selectively expressed on tumor-infiltrating regulatory T cells (Tregs). Strong immunosuppression …
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CCR8 antagonist suppresses liver cancer progression via ... - PubMed
Apr 4, 2025 · IPG0521m inhibited liver cancer growth via reducing the immunosuppressive function of Tregs, thereby boosting anti-cancer immunity. Our study paves the way for the …
CCR4, CCR8, and P2RY14 as Prognostic Factors in Head and Neck …
Feb 22, 2021 · The expression of CCR4 (A), CCR8 (B), and P2RY14 (C) were all significantly correlated with patient prognosis in the TCGA data set, and the higher the level of gene …
Abstract 6694: Highly selective anti-CCR8 antibody …
Aug 15, 2020 · BMS-986340 (anti-CCR8 hIgG1-nonfucosylated [NF] antibody) was developed and used for CCR8+ Treg depletion in human tumor explants. Results: CCR8 gene expression had the highest correlation with FOXP3 in …
Apr 27, 2018 · In this study, the expression levels of CCL18 and its receptor CCR8 and their correlation with the clinicopathological characteristics and prognosis in patients with GC were …
