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Cell Press
https://www.cell.com › trends › immunology › fulltext
CCR8: a promising therapeutic target against tumor …
Jan 30, 2025 · Recent studies demonstrate that CC chemokine receptor (CCR)8 is highly and specifically expressed on effector TI-Treg cells in mice and humans, highlighting CCR8 as a promising target for selective TI-Treg cell depletion in …
American Society of Hematology
https://ashpublications.org › bloodadvances › article
CCR8 is a new therapeutic target in cutaneous T-cell …
Jun 10, 2022 · CCR8 engagement by its ligands CCL18 and CCL1 induced a significant Erk1/2 phosphorylation at 30 minutes and was independent on IL-2 in tumor cells of Sézary patients (Figure 1D).
American Association of Immunologists
https://journals.aai.org › ...
Cutting Edge: CCR8 Signaling Regulates IL-25– and IL …
Nov 3, 2023 · In this study, we identified a role for the chemokine receptor CCR8 in modulating skin ILC2 abundance and activation. CCR8 signaling facilitated IL-25–induced increases in skin and lung ILC2s, ILC2 activation and systemic IL …
Studies of CCR8 IL-2
National Center for Biotechnology Information
CCR8 Expression Defines Tissue-Resident Memory T Cells in Human Skin
Human skin harbors two major T cell compartments of equal size that are distinguished by expression of the chemokine receptor CCR8. In vitro studies have demonstrated that CCR8 expression is regulated by TCR engagement and the skin tissue microenvironment. To extend these observations, we examined t...
Author: Michelle L. Mc…
Published: 2018/03/03
Publication: J Immuno…
PubMed
Cutting Edge: CCR8 Signaling Regulates IL-25- and IL-33-Responsive Skin Group 2 Innate Lymphoid Cell Migration and Function
Group 2 innate lymphoid cells (ILC2s) are sentinels of barrier immunity, and their activation by the epithelial alarmins IL-25 and IL-33 is a defining trait. In this study, we identified a role for the chemokine receptor CCR8 in modulating skin ILC2 abundance and activation. CCR8 signaling facilitat...
Author: Zhengwang Sun
Published: 2023/12/15
Keywords: National In…
ResearchGate
Cutting Edge: CCR8 Signaling Regulates IL-25– and IL-33–Responsive Skin Group 2 Innate Lymphoid Cell Migration and Function
Group 2 innate lymphoid cells (ILC2s) are sentinels of barrier immunity, and their activation by the epithelial alarmins IL-25 and IL-33 is a defining trait. In this study, we identified a role for the chemokine receptor CCR8 in modulating skin ILC2 abundance and activation. CCR8 signaling facilitat...
Published: 2023/11/03
DOI: 10.4049/jimmunol.…
National Center for Biotechnology Information
CCR8 Is Expressed by Antigen-Elicited, IL-10-Producing CD4+ CD25+ T Cells, Which Regulate Th2-Mediated Granuloma Formation in Mice1
CCR8 was initially described as a Th2 cell-restricted receptor, but this has not been fully tested in vivo. The present study used ex vivo and in vivo approaches to examine the distribution and functional significance of CCR8 among CD4+ T cells. Populations of cytokine-secreting CD4+ T cells were ge...
Author: Christine M. Fr…
Published: 2005/02/02
DOI: 10.4049/jimmunol.…
Bristol Myers Squibb
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CC Chemokine Receptor 8 (CCR8) Immune Pathway Fact Sheet
Mar 23, 2021 · CC chemokine receptor 8 (CCR8) is a protein found mainly on the surface of a highly immunosuppressive subset of regulatory T cells (Tregs) within tumors. It is a regulator …
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Nature
https://www.nature.com › articles
The impact of CCR8+ regulatory T cells on cytotoxic T cell ... - Nature
Mar 30, 2022 · CCR8+ cells were magnetically removed from TICs of lung cancer and cultured with IL-2 and CpG. After 5 days, CD8 T cells in TICs were detected by flow cytometry.
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
CCR8 Signaling Regulates IL-25- and IL-33-Responsive Skin Group …
Here we identified a role for the chemokine receptor CCR8 in modulating skin ILC2 abundance and activation. CCR8 signaling facilitated IL-25 induced increases in skin and lung ILC2s, ILC2 …
People also ask
What does CCR8 expression define?
CCR8 expression defines tissue-resident memory T cells in human skin. Skin effector memory T cells do not recirculate and provide immune protection in alemtuzumab-treated CTCL patients. Therapeutic depletion of CCR8 + tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy
CCR8 is a new therapeutic target in cutaneous T-cell lymphomas
ashpublications.org
What is CCR8 and why is it important?
CCR8 is a protein found mainly on the surface of a highly immunosuppressive subset of regulatory T cells (Tregs) within tumors. It is important as a regulator of immune response. As a chemokine receptor, CCR8 serves as a mediator of activity in concert with its chemokine CC chemokine ligand 1 (CCL1).1,2
CC Chemokine Receptor 8 (CCR8) Immune Pathway Fact Sheet
bms.com
Is CCR8 a tissue-specific chemokine system?
The physiological relevance of CCR8 expression is presently unclear, but it may be important for T rm cell localization to areas of chemokine production in skin tissue. CCL1, the selective ligand for CCR8, is preferentially expressed in human skin, providing support for the notion of a tissue-specific chemokine system ( 15 ).
CCR8 Expression Defines Tissue-Resident Memory T Cells in Human Skin
ncbi.nlm.nih.gov
Is CC chemokine receptor (CCR)8 a target for selective Ti-Treg cell depletion?
Recent studies demonstrate that CC chemokine receptor (CCR)8 is highly and specifically expressed on effector TI-Treg cells in mice and humans, highlighting CCR8 as a promising target for selective TI-Treg cell depletion in the treatment of various cancers.
CCR8: a promising therapeutic target against tumor-infiltrating
cell.com
Why is CCR8 important for Ti-Treg cells?
Recent studies show that CCR8 is a well-recognized marker of activation for TI-Treg cells in mice and humans, and is possibly responsible for Treg cell functions, differentiation, migration, and survival [6–8]. CCR8 is preferentially expressed on TI-Treg cells, especially those exhibiting highly immunosuppressive properties [9, 10].
CCR8: a promising therapeutic target against tumor-infiltrating
cell.com
How is CCR8 regulated in human skin?
Human skin harbors two major T cell compartments of equal size that are distinguished by expression of the chemokine receptor CCR8. In vitro studies have demonstrated that CCR8 expression is regulated by TCR engagement and the skin tissue microenvironment.
CCR8 Expression Defines Tissue-Resident Memory T Cells in Human Skin
ncbi.nlm.nih.gov
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National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
CCR8 Expression Defines Tissue-Resident Memory T Cells in …
Mar 1, 2018 · The proliferation of flow-sorted CCR8 + and CCR8 − skin T cells in response to coculture with autologous skin DCs in the presence of IL-15 or IL-7 + IL-15, or stimulation with …
Springer
https://link.springer.com › article
Development of a cellular model to study CCR8 signaling in tumor ...
Jan 17, 2024 · Taken together, these findings revealed that all the tested factors (CD3/CD28 activator, IL-2, VitD3 and TCM231) can contribute to the upregulation of CCR8 in Tregs, with …
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
CCR8 as a Therapeutic Novel Target: Omics-Integrated …
In this study, we conducted an extensive bioinformatics analysis integrating genomics, proteomics, and transcriptomics data to establish CCR8 as a promising anti-cancer drug target.
PubMed
https://pubmed.ncbi.nlm.nih.gov
Cutting Edge: CCR8 Signaling Regulates IL-25- and IL-33
Dec 15, 2023 · In this study, we identified a role for the chemokine receptor CCR8 in modulating skin ILC2 abundance and activation. CCR8 signaling facilitated IL-25-induced increases in …
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CCR8: a promising therapeutic target against tumor …

CCR8 is a new therapeutic target in cutaneous T-cell …

Cutting Edge: CCR8 Signaling Regulates IL-25– and IL …

CC Chemokine Receptor 8 (CCR8) Immune Pathway Fact Sheet

The impact of CCR8+ regulatory T cells on cytotoxic T cell ... - Nature

CCR8 Signaling Regulates IL-25- and IL-33-Responsive Skin Group …

CCR8 is a new therapeutic target in cutaneous T-cell lymphomas

CC Chemokine Receptor 8 (CCR8) Immune Pathway Fact Sheet

CCR8 Expression Defines Tissue-Resident Memory T Cells in Human Skin

CCR8: a promising therapeutic target against tumor-infiltrating

CCR8: a promising therapeutic target against tumor-infiltrating

CCR8 Expression Defines Tissue-Resident Memory T Cells in Human Skin

CCR8 Expression Defines Tissue-Resident Memory T Cells in …

Development of a cellular model to study CCR8 signaling in tumor ...

CCR8 as a Therapeutic Novel Target: Omics-Integrated …

Cutting Edge: CCR8 Signaling Regulates IL-25- and IL-33

Related searches for CCR8 IL-2

Related searches for CCR8 IL-2