Chemokine (C-C motif) receptor 8, also known as CCR8, is a protein which in humans is encoded by the CCR8 gene. [5] CCR8 has also recently been designated CDw198 (cluster of differentiation w198).

Mar 23, 2021 · CC chemokine receptor 8 (CCR8) is a protein found mainly on the surface of a highly immunosuppressive subset of regulatory T cells (Tregs) within tumors. It is a regulator of immune response.1,2. Receptors like CCR8 and their chemokines play an important role in the immune system’s response to cancer.

Mar 30, 2022 · Recent studies identified selective CCR8 expression on tumor-infiltrating Tregs; CCR8+ Tregs have been indicated as a possible new target of cancer immunotherapy. Here, we investigated the...

High levels of expression of chemokine (C-C motif) receptor 8 (CCR8) discriminate Treg cells within tumours from those found in systemic lymphoid tissues. It has recently been proposed that disruption of CCR8 function using blocking anti-CCR8 antibodies results in reduced accumulation of Treg cells within tumours and disruption of their ...

CCR8 is expressed by a small and heterogeneous population of peripheral blood CD4 memory T cells enriched in T helper type 2 (Th2) effector and T regulatory (Treg) cells. CCR8 mediates rescue from dexamethasone-induced apoptosis via an ERK-dependent pathway

Dec 1, 2023 · Here, authors generated mAb1, an antagonist antibody against CCR8 and determined structures of CCR8 in complex with mAb1 or the agonist CCL1, providing insights into CCR8 inhibition and...

Jan 30, 2025 · Recent studies demonstrate that CC chemokine receptor (CCR)8 is highly and specifically expressed on effector TI-Treg cells in mice and humans, highlighting CCR8 as a promising target for selective TI-Treg cell depletion in the treatment of various cancers.

Mar 30, 2025 · CCR8 (C-C Motif Chemokine Receptor 8) is a Protein Coding gene. Diseases associated with CCR8 include Molluscum Contagiosum and Kaposi Sarcoma. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

Learn about CC chemokine receptor 8, its role in cancer, and how BMS researchers investigate antibody-mediated Treg depletion targeting CCR8 as an immunotherapy mechanism.

Specific depletion of CCR8 + ti-Tregs, but not CCR8 blockade, results in reduced LLC-OVA tumor growth and synergizes with anti-PD-1 therapy. (A) Schematic overview of tetravalent Nb-Fc generation. (B) Delta-MFI of CCR8 expression on ti-Tregs of isotype (black) or anti-CCR8 (block) (red) treated mice (n=5).