CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti
Oct 15, 2020 · CC chemokines (or β-chemokines) are 28 chemotactic cytokines with an N-terminal CC domain that play an important role in immune system cells, such as CD4 + and …
- Author: Jan Korbecki, Szymon Grochans, Izabela Gutowska, Katarzyna Barczak, Irena Baranowska-Bosiacka
- Publish Year: 2020
Other content from pubmed.ncbi.nlm.nih.govC-C chemokine receptor type 6 - Wikipedia
Chemokine receptor 6 also known as CCR6 is a CC chemokine receptor protein which in humans is encoded by the CCR6 gene. CCR6 has also recently been designated CD196 (cluster of differentiation 196). The gene is located on the long arm of Chromosome 6 (6q27) on the Watson (plus) strand. It is 139,737 bases long and encodes a protein of 374 amino acids (molecular weight 42,4…
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CCR6 Regulates the Migration of Inflammatory and …
In this study, we report that both Treg and Th17 cells express CCR6. Th17 cells also express the CCR6 ligand CCL20, through which Th17 promotes the migration of Th17 and Treg cells. CCR6 deficiency in T cells decreases the …
The impact of CCR8+ regulatory T cells on cytotoxic T cell ... - Nature
Mar 30, 2022 · Recent studies identified selective CCR8 expression on tumor-infiltrating Tregs; CCR8+ Tregs have been indicated as a possible new target of cancer immunotherapy. Here, …
CCR6 defines a subset of activated memory T cells of Th17 …
In this study, we aimed to investigate the phenotype and functional characteristics of circulating CCR6 + T cells in blood from chronic ITP patients and healthy controls. We found that the …
The chemokine receptor CCR8 promotes the migration of …
Sep 9, 2018 · We defined a CCR8-dependent stepwise mechanism of DC subset-specific migration, through which LN CD169 + SIGN-R1 + macrophages control the polarization of the …
- Author: Caroline L. Sokol, Ryan B. Camire, Michael C. Jones, Andrew D. Luster
- DOI: 10.1016/j.immuni.2018.07.012
- Publish Year: 2018
- Published: 2018/09/09
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CC Chemokines in a Tumor: A Review of Pro-Cancer …
Oct 15, 2020 · In this review, we discuss human CC motif chemokine ligands: CCL1, CCL3, CCL4, CCL5, CCL18, CCL19, CCL20, CCL21, CCL25, CCL27, and CCL28 (CC motif chemokine receptor CCR5, CCR6, CCR7, CCR8, CCR9, …
Structural basis of antibody inhibition and chemokine ... - Nature
Dec 1, 2023 · Here, authors generated mAb1, an antagonist antibody against CCR8 and determined structures of CCR8 in complex with mAb1 or the agonist CCL1, providing insights …
Chemokine Receptor CCR6 - an overview | ScienceDirect Topics
Chemokine receptor CCR6 is expressed on various cells such as B cells, immature dendritic cells, innate lymphoid cells (ILCs), regulatory CD4 T cells, and Th17 cells. CCL20 is the only known …
Differential expression of CCR8 in tumors versus normal tissue …
We show that CCR8 gene expression is restricted to tumor resident Tregs, and that CCR8 protein is expressed at higher densities on tumor resident Tregs than on other tumor resident T cells …
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