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nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Systematic Assessment of Chemokine Signaling at Chemokine …
Chemokine ligands differentially inhibit cAMP synthesis via CCR4, CCR7 and CCR10. (a) The principle of the BRET-based cAMP assay. Upon activation of a chemokine receptor, the …
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ResearchGate
https://www.researchgate.net › publication
(PDF) Systematic Assessment of Chemokine Signaling …
Apr 19, 2021 · Chemokine ligands differentially inhibit cAMP synthesis via CCR4, CCR7 and CCR10. (a) The principle of the BRET-based cAMP assay. Upon activation of a chemokine receptor, the dissociated Gαi/o...
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  Nathan Vanalken
  Figure 3. Chemokine Ligands Differentially Inhibit cAMP Synthesis Via
  Anne Steen
  Pallavi Patel
  Yeon Ho Choi
euroscreenfast.com
https://euroscreenfast.com › assays
Chemokine CCR4 cAMP (FAST-069C) - EuroscreenFast
human CCR4 receptor is also validated for Aequorin (calcium), GTPγS and radioligand binding competition assays
Studies of CCR4 Camp
ResearchGate
Systematic Assessment of Chemokine Signaling at Chemokine Receptors CCR4, CCR7 and CCR10
Chemokines interact with chemokine receptors in a promiscuous network, such that each receptor can be activated by multiple chemokines. Moreover, different chemokines have been reported to preferentially activate different signalling pathways via the same receptor, a phenomenon known as biased agoni...
Author: Herman D. Li…
Published: 2021/04/19
DOI: 10.3390/ijms2208…
PubMed
The C-C Chemokines CCL17 and CCL22 and Their Receptor CCR4 in CNS Autoimmunity
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). It affects more than two million people worldwide, mainly young adults, and may lead to progressive neurological disability. Chemokines and their receptors have been shown to play critical ro...
Author: Stefanie Scheu
Published: 2017/11/02
Keywords: CCL17; CC…
PubMed
CC Chemokine Receptor 4 (CCR4) as a Possible New Target for Therapy
Chemokines and their receptors participate in many biological processes, including the modulation of neuroimmune interactions. Approximately fifty chemokines are distinguished in humans, which are classified into four subfamilies based on the N-terminal conserved cysteine motifs: CXC, CC, C, and CX3...
Author: Joanna Bogacka
Published: 2022/12/09
Keywords: CCL17; CC…
PubMed
CCR4 as a Therapeutic Target for Cancer Immunotherapy
CCR4 is a chemokine receptor mainly expressed by T cells. It is the receptor for two CC chemokine ligands, CCL17 and CCL22. Originally, the expression of CCR4 was described as highly selective for helper T type 2 (Th2) cells. Later, its expression was extended to other T cell subsets such as regulat...
Author: Osamu Yoshie
Published: 2021/11/04
Keywords: ATLL; CCR…
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
Internalization of the chemokine receptor CCR4 can be evoked by ...
Apr 15, 2022 · We describe four small molecule antagonists that were demonstrated to bind to two distinct allosteric sites on the CCR4 receptor, and while both classes inhibited agonist …
Nature
https://www.nature.com › articles
Identification of a non-canonical chemokine-receptor pathway ...
Jan 22, 2024 · Determining cAMP levels in CCR4- or CCR8-transfected HEK293 cells confirmed that CCL17 induced G i-signaling via both receptors. This extends findings that CCR8 …
- Author: Yvonne Döring
nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
CCL17, CCL22 and their receptor CCR4 in hematologic malignancies
More and more studies have shown that the interaction of C–C chemokine ligand 17 (CCL17) and C–C chemokine ligand 22 (CCL22) with the receptor C–C chemokine receptor type 4 (CCR4) …
People also ask
Does CCR4 play a role in CNS autoimmunity?
The C-C class chemokines 17 (CCL17) and 22 (CCL22) and their C-C chemokine receptor 4 (CCR4) have been shown to play an important role in homeostasis and inflammatory responses. Here, we provide an overview of the involvement of CCR4 and its ligands in CNS autoimmunity.
The C-C Chemokines CCL17 and CCL22 and Their Receptor CCR4 in ... - PubMed
pubmed.ncbi.nlm.nih.gov
What is CC chemokine receptor 4?
Recent studies provide new evidence that CC chemokine receptor 4 (CCR4) is important in the pathogenesis of many diseases, such as diabetes, multiple sclerosis, asthma, dermatitis, and cancer. This review briefly characterizes CCR4 and its ligands (CCL17, CCL22, and CCL2), and their contributions to immunological and neoplastic diseases.
CC Chemokine Receptor 4 (CCR4) as a Possible New Target for Therapy
pubmed.ncbi.nlm.nih.gov
Does CCR4 play a role in neoplastic diseases?
This review briefly characterizes CCR4 and its ligands (CCL17, CCL22, and CCL2), and their contributions to immunological and neoplastic diseases. The review notes a significant role of CCR4 in nociceptive transmission, especially in painful neuropathy, which accompanies many diseases.
CC Chemokine Receptor 4 (CCR4) as a Possible New Target for Therapy
pubmed.ncbi.nlm.nih.gov
What does CCR7 do?
CCR7 is a key receptor guiding cDCs into T cell rich regions of lymphatic organs, enabling them to stimulate or suppress T cell immunity 31. CCR7 has also been implicated in mediating egress of antigen-presenting cells from atherosclerotic lesions 32.
Identification of a non-canonical chemokine-receptor pathway
nature.com
Does CCR4 deficiency phenocopy T reg cells?
To date, CCR4 is the only cognate signaling receptor for CCL17 identified and known to contribute to the recruitment and in vivo functions of T reg cells 18. Yet, CCR4 deficiency did not phenocopy the effects on T reg cells and protection from atherosclerosis seen in CCL17-deficient mice 10.
Identification of a non-canonical chemokine-receptor pathway
nature.com
Where is CCR8 expressed?
CCR8 is mainly expressed on CD4 + T cells and specifically on T reg cells 39, 40 but also present on monocytes, natural killer (NK) cells, group 2 innate lymphoid cells and DCs, depending on disease context and tissue location 41, 42, 43.
Identification of a non-canonical chemokine-receptor pathway
nature.com
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PubMed
https://pubmed.ncbi.nlm.nih.gov
The C-C Chemokines CCL17 and CCL22 and Their Receptor CCR4 …
Nov 2, 2017 · The C-C class chemokines 17 (CCL17) and 22 (CCL22) and their C-C chemokine receptor 4 (CCR4) have been shown to play an important role in homeostasis and …
- Author: Stefanie Scheu, Shafaqat Ali, Christina Ruland, Volker Arolt, Judith Alferink
- Publish Year: 2017
ResearchGate
https://www.researchgate.net › figure › Chemokine...
Chemokine ligands differentially inhibit cAMP synthesis …
Chemokine ligands differentially inhibit cAMP synthesis via CCR4, CCR7 and CCR10. (a) The principle of the BRET-based cAMP assay. Upon activation of a chemokine receptor, the...
PubMed
https://pubmed.ncbi.nlm.nih.gov
CC Chemokine Receptor 4 (CCR4) as a Possible New Target for …
Dec 9, 2022 · Recent studies provide new evidence that CC chemokine receptor 4 (CCR4) is important in the pathogenesis of many diseases, such as diabetes, multiple sclerosis, asthma, …
R&D Systems
https://www.rndsystems.com › pathways › chemokine...
Chemokine Signaling Pathways - R&D Systems
Chemokines activate their target cells by signaling through seven transmembrane G protein-coupled receptors (GPCRs).
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Systematic Assessment of Chemokine Signaling at Chemokine …

(PDF) Systematic Assessment of Chemokine Signaling …

Chemokine CCR4 cAMP (FAST-069C) - EuroscreenFast

Internalization of the chemokine receptor CCR4 can be evoked by ...

Identification of a non-canonical chemokine-receptor pathway ...

CCL17, CCL22 and their receptor CCR4 in hematologic malignancies

The C-C Chemokines CCL17 and CCL22 and Their Receptor CCR4 in ... - PubMed

CC Chemokine Receptor 4 (CCR4) as a Possible New Target for Therapy

CC Chemokine Receptor 4 (CCR4) as a Possible New Target for Therapy

Identification of a non-canonical chemokine-receptor pathway

Identification of a non-canonical chemokine-receptor pathway

Identification of a non-canonical chemokine-receptor pathway

The C-C Chemokines CCL17 and CCL22 and Their Receptor CCR4 …

Chemokine ligands differentially inhibit cAMP synthesis …

CC Chemokine Receptor 4 (CCR4) as a Possible New Target for …

Chemokine Signaling Pathways - R&D Systems