CCR4 is a cell-surface protein and should not be confused with the unrelated carbon catabolite repression-negative on TATA-less (CCR4-Not), a nuclear protein complex that regulates gene expression.

CCR4 is a chemokine receptor selectively expressed on normal T cell subsets such as type 2 helper T cells, skin-homing T cells and regulatory T cells, and on skin-associated T cell malignancies such as adult T cell leukemia/lymphoma (ATLL), which is ...

Mar 30, 2025 · CCR4 (C-C Motif Chemokine Receptor 4) is a Protein Coding gene. Diseases associated with CCR4 include Mycosis Fungoides and Peripheral T-Cell Lymphoma. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

This article is a brief overview of basic and clinical research on CCR4 and its ligands, which has eventually led to the development of a humanized defucosylated anti-CCR4 antibody 'Mogamulizumab' for treatment of relapsed/refractory ATL and CTCLs.

Nov 4, 2021 · CCR4 is a chemokine receptor mainly expressed by T cells. It is the receptor for two CC chemokine ligands, CCL17 and CCL22. Originally, the expression of CCR4 was described as highly selective for helper T type 2 (Th2) cells. Later, its expression was extended to other T cell subsets such as regulat …

Expression of CC chemokine receptor 4 (CCR4) by tumor cells is associated with skin involvement, but CCR4 also has an important role in normal and tumor immunity.

Aug 2, 2014 · This article is a brief overview of basic and clinical research on CCR4 and its ligands, which has eventually led to the development of a humanized defucosylated anti-CCR4 antibody ‘Mogamulizumab’ for treatment of relapsed/refractory ATL and CTCLs.

Findings suggest that C-C motif chemokine receptor 4 (CCR4) may be a potential new diagnostic and prognostic marker in hepatocellular carcinoma (HCC), and targeting CCR4 may be a potential therapeutic option for blocking HCC metastasis

Dec 9, 2022 · Recent studies provide new evidence that CC chemokine receptor 4 (CCR4) is important in the pathogenesis of many diseases, such as diabetes, multiple sclerosis, asthma, dermatitis, and cancer. This review briefly characterizes CCR4 and its ligands (CCL17, CCL22, and CCL2), and their contributions to immunological and neoplastic diseases.

CC chemokine receptor 4 (CCR4) is a receptor of CC chemokine ligand 22 (CCL22) and CC chemokine ligand 17 (CCL17) and can affect the function of T helper type 2 (Th2) and regulatory T cells (Tregs). CCR4 is expressed on the surface of T lymphocytes, NK cells, monocytes, macrophages, and eosinophils (11).