The CCND1 gene encodes the cyclin D1 protein. The human CCND1 gene is located on the long arm of chromosome 11 (band 11q13). It is 13,388 base pairs long, and translates into 295 amino acids. [7] Cyclin D1 is expressed in all adult human tissues with the exception of cells derived from bone marrow stem cell lines (both lymphoid and myeloid). [8 ...

Mar 30, 2025 · CCND1 (Cyclin D1) is a Protein Coding gene. Diseases associated with CCND1 include Myeloma, Multiple and Von Hippel-Lindau Syndrome. Among its related pathways are Defective binding of RB1 mutants to E2F1, (E2F2, E2F3) and Regulation of activated PAK-2p34 by proteasome mediated degradation.

Feb 9, 2025 · CCND1 mutations increase protein stability and promote ibrutinib resistance in mantle cell lymphoma. Mohanty A, et al. Oncotarget, 2016 Nov 8. PMID 27713153, Free PMC Article. Expression profile and molecular genetic regulation of cyclin D1 expression in epithelioid sarcoma. Lin L, et al. Mod Pathol, 2005 May. PMID 15578074.

Cyclin D1 is a 36-kDa protein encoded by CCND1 gene, located on chromosome 11q13. Cyclin D1 is expressed by the majority of normal human cells apart from cells derived from bone marrow stem cell lines [8].

May 16, 2016 · Cyclin D1 (Ccnd1) together with its binding partner Cdk4 act as a transcriptional regulator to control cell proliferation and migration, and abnormal Ccnd1·Cdk4 expression promotes tumour...

Jan 5, 2025 · Clinical resource with information about CCND1, A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age., Colorectal cancer, Genetic variants associated with breast size also influence breast cancer risk., Genome-wide ...

CCND1 is associated with cancer development and is frequently overexpressed in various human cancer cells and tissues, including gastric cancer [20, 21]. As an oncogene that promotes cell cycle progression, high CCND1 expression is related to increased cancer cell growth and proliferation and decreased cell apoptosis .

Jul 27, 2024 · The findings of this study provide valuable insights into the role of CCND1 in cancer diagnosis and progression, and its potential for targeted therapies. CCND1 could be used as a potential diagnostic biomarker for the COAD, ESCA, KIRC, READ, STAD, and THCA stages.

Chromosome 11: 69,455,855-69,469,242 forward strand. GRCh37:CM000673.1. This gene has 6 transcripts (splice variants), 10 paralogues and is associated with 57 phenotypes. Show transcript table.

Feb 9, 2025 · Atox1-cyclin D1 loop activity is critical for survival of tumor cells with inactivated TP53. MAT1A activation of glycolysis to promote NSCLC progression depends on stabilizing CCND1. Long Noncoding RNAs PTPRG Antisense RNA 1 Targets Cyclin D1 to Facilitate Cell Proliferation in Lung Adenocarcinoma.