Chemokine (C-C motif) ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family. This chemokine is also known as 6Ckine (because it has six conserved cysteine …

CCL21 promotes immune activity in the tumor microenvironment (TME) by colocalizing dendritic cells (DC) and T cells programing ectopic lymph node architectural structures that correlate …

Mar 30, 2025 · CCL21 (C-C Motif Chemokine Ligand 21) is a Protein Coding gene. Diseases associated with CCL21 include Periapical Periodontitis and Central Nervous System …

CCL21 is critical in mediating activated DCs and T cells to lymph system niches and triggering subsequent immune response to foreign antigen, therefore providing the rationale for CCL21 …

In this review we discuss our experience with efforts to restore host APC and T cell activities in the lung cancer microenvironment by intratumoral administration of dendritic cells (DC) …

CCL21 is a homeostatic chemokine constitutively produced in secondary lymphoid organs (SLOs) where it is involved in CCR7 + naïve and central memory T-cell homing via high endothelial …

CCL21/CCR7 prevents apoptosis by upregulating the expression of bcl-2 and by downregulating the expression of bax and caspase-3 potentially via the ERK pathway in non-small cell lung …

CCL21 is a risk factor for Rheumatoid arthritis (RA). CCL21 is highly elevated in RA synovial fluid and attracts circulating monocytes into the inflamed joint. CCL21 differentiates monocytes into …

Chemokine ligand 21 (CCL21) is the known high-affinity ligand that binds to CCR7 and drives cell migration in tissues. CCL21 is mainly produced by stromal cells and lymphatic endothelial …

Sep 23, 2022 · We recently identified altered levels of chemokine CCL21 in SSc associated pulmonary arterial hypertension (PAH). Here, we aimed to define target organ expression and …