Results: Screening of primary tumour cells expressing YAP S127A identified CC chemokine ligand 2 (Ccl2) as a macrophage chemoattractant, whose expression was regulated in a …

Aug 30, 2021 · Screening of primary tumour cells expressing YAP S127A identified CC chemokine ligand 2 (Ccl2) as a macrophage chemoattractant, whose expression was …

Mar 27, 2025 · By acting on NF2 and 14-3-3theta, ERα enhanced YAP phosphorylation and attenuated the nuclear translocation of YAP, thereby suppressing CCL2 expression. It also …

Mar 27, 2025 · ERα/YAP/CCL2 signaling reduced M2 macrophages infiltration to inhibit HCC progression, revealing the effect of ERα in cancer cells on immune cells in HCC …

The oncogene YAP controls cell-cell communication to create a pro-tumorigenic microenvironment in liver can-cer. Exemplified for its direct target gene CCL2, we show that …

YAP overexpression in macrophages is a characteristic of M2 macrophages, which highly express anti-inflammatory cytokines and promote epithelial wound healing. When YAP is knocked …

1 day ago · For YAP S127A overexpression in the TetO-YAP mice, 1 x 10 11 GC of AAV-TBG-Cre were administered to 8-week old TetO-YAP mice, two weeks later, YAP S127A …

Apr 6, 2025 · Thomann, S. et al. YAP-induced Ccl2 expression is associated with a switch in hepatic macrophage identity and vascular remodelling in liver cancer. Liver Int. 41, 3011–3023 …

Aug 30, 2021 · Screening of primary tumor cells expressing YAP S127A identified CC chemokine ligand 2 (Ccl2) as a macrophage chemoattractant, whose expression was regulated in a …

These data suggest that both YAP and TAZ bind to the Ccl2 promoter. Together, these data suggest that YAP and TAZ differentially regulate expression of many genes in liver tumors, …