CCL2: An Important Mediator Between Tumor Cells and Host Cells …
Typical stimulations leading to CCL2 expression include TNFα, IL-1β, and phorbol-12-Myristate-13-Acetate (PMA) treatment. Tumor antigens can reprogram inflammatory cells and promote …
CCL2 - Wikipedia
CCL2 is a small cytokine that belongs to the CC chemokine family. CCL2 tightly regulates cellular mechanics [5] and thereby recruits monocytes, memory T cells, and dendritic cells to the sites …
Tissue factor regulates microvessel formation and stabilization by ...
Endogenous TF regulates CCL2 production in endothelial cells. Secreted CCL2 mediates the angiogenic effect of TF by recruiting smooth muscle cells toward endothelial cells and …
EGR1 and RXRA transcription factors link TGF-β pathway and CCL2 …
Jul 8, 2021 · Here, we studied the behavior of the CCL2 gene in MDA-MB-231 and HCC1937 breast cancer cells representing mesenchymal-like phenotype activated by TGF-β. Using …
Insights into CC Chemokine Ligand 2/Chemokine Receptor 2 …
Jun 1, 2017 · Chemokine ligand 2 (CCL2), also known as monocyte chemoattractant protein 1 (MCP-1), is a chemokine that recruits immune cells to inflammatory sites by interacting with G …
CCL2 Shapes Macrophage Polarization by GM-CSF and M-CSF: …
Apr 15, 2014 · CCL2 and CCR2 were found to determine the extent of macrophage polarization because CCL2 enhances the LPS-induced production of IL-10, whereas CCL2 blockade leads …
PIM1/NF-κB/CCL2 blockade enhances anti-PD-1 therapy response …
Jul 14, 2024 · Our research identifies that the ablation of the Pim-1 proto-oncogene (PIM1) in non-small cell lung cancer (NSCLC) suppresses TAM infiltration and prevents them from polarizing …
JCI - Targeting lactylation and the STAT3/CCL2 axis to overcome ...
Apr 1, 2025 · Targeting ENSA-K63 lactylation or CCL2/CCR2 signaling reprograms the TME and enhances the efficacy of immune checkpoint blockade (ICB) in PDAC preclinical models. This …
Tumor treating fields enhance anti-PD therapy by improving CCL2…
Mar 17, 2025 · CCL2/8-CCR2 and CXCL9/10-CXCR3 could serve as potential biomarkers for predicting patient response to TTFields and anti-PD therapy in NSCLC. Monitoring chemokine …
Estrogen receptor α suppresses hepatocellular carcinoma by …
Mar 27, 2025 · It also acted as a transcription factor that regulated CCL2 expression at the transcriptional level. ERα/YAP/CCL2 signaling reduced M2 macrophages infiltration to inhibit …