May 20, 2020 · Our present findings support an increase in amyloidosis following CCL2 overexpression in the brain of APP/PS1 mice. Moreover, we found a decrease in soluble β …

However, PS1 M146L mice with CCL2 deficiency led to decreased Dcx + and BrdU + /NeuN + neuronal numbers at 7 months of age. This suggests a potential synergistic effect between the …

Here, we report that adeno-associated virus (AAV) serotype 1 and 2 hybrid efficiently deliver 7ND gene, a dominant-negative CCL2 mutant, in a dose-response manner and express >1,000-fold …

Notably, β-amyloidosis occurs through oligomer formation that evolves into diffuse and eventually TS + -compact plaques. To examine how CCL2 deficiency affects β-amyloidosis, …

Here we report that adeno-associated virus (AAV) serotype 1 and 2 hybrid efficiently deliver 7ND gene, a dominant-negative CCL2 mutant, in dose-response manner and express up to 1000 …

CCL2 and C-C chemokine receptor type 2 (CCR2) protein levels in the mouse hippocampus were analyzed by western blotting. The results showed that APP/PS1 mice with chronic neuropathic …

dominant-negative ccl2 suppresses gliosis and β-amyloidosis in aged APP/Ps1 bigenic mice red to Tg2576.29 Based on our previous results, we hypothesized that treatment of APP/PS1 mice …

Feb 1, 2015 · Transgenic APP/PS1 mice lacking CB2 showed reduced percentages of microglia and infiltrating macrophages. Furthermore, they showed lowered expression levels of pro …

Our data now demonstrate that CCL2-CCR2 signaling affects a range of microglia and neuroprogenitor cell functions that not only influence disease pathobiology, but also may be …

Dec 7, 2020 · We have identified a new mechanism where microglia release CCL2 to migrate to Aβ and phagocytose this peptide.