Mesenchymal stromal cell derived CCL2 is required for ... - Nature
Feb 14, 2020 · CCL2 is a potent cytokine involved in the recruitment of macrophages. We hypothesised that MSC derived CCL2 may be involved in the MSC therapeutic effect by …
CCL2 and CXCL12 Derived from Mesenchymal Stromal Cells ... - PubMed
Feb 11, 2020 · We identify that BM-MSC-secreted chemokine ligand 2 (CCL2) and C-X-C motif chemokine 12 (CXCL12) cooperate as a heterodimer to upregulate IL-10 expression in CCR2 …
CCL2 and CXCL12 Derived from Mesenchymal Stromal Cells …
Feb 11, 2020 · In our present study, clodronate pre-treatment of colitic mice confirms the essential role of endogenous macrophages in bone-marrow-derived MSC (BM-MSC)-mediated clinical …
Macrophages at the nexus of mesenchymal stromal cell potency: …
The contribution of MSC‐borne chemokines, CCL2 in particular, and the recently recognized biological role of CC/CXC chemokine heterodimers found in MSC secretome as potent agents …
Mesenchymal stromal cell derived CCL2 is required for
Feb 14, 2020 · Mesenchymal stromal cells (MSC) have immunomodulatory effects impacting macrophages, promoting polarisation towards a reparative phenotype. CCL2 is a potent …
Activated mesenchymal stem/stromal cells promote myeloid cell ...
Single-cell RNA sequence analysis in human bone marrow cells confirms the significance of MSC-derived CCL2 in cell fate determination, providing valuable insights on the in vivo effects …
Enhancing the Therapeutic Potential of CCL 2-Overexpressing ... - PubMed
Oct 21, 2020 · Although intravenous administration of mesenchymal stem cells (MSCs) is effective for experimental stroke, low engraftment and the limited functional capacity of …
Impaired B Cell Inhibition by Lupus Bone Marrow Mesenchymal …
Nov 15, 2014 · Knockdown of CCL2 in normal MSC damaged their suppressive capacity for B cells. Conversely, overexpression of CCL2 in lupus MSCs restored their immunoregulatory …
CCR2-overexpressing mesenchymal stem cells targeting damaged …
Feb 5, 2022 · By evaluating the chemokine expression profile in the liver of ALF patients and ALF mice, we found that CCL2 expression was highly upregulated in damaged livers, while the …
Mesenchymal stromal cell derived CCL2 is required for accelerated …
Feb 14, 2020 · Mesenchymal stromal cells (MSC) have immunomodulatory effects impacting macrophages, promoting polarisation towards a reparative phenotype. CCL2 is a potent …