- We found that CCL1 secreted by macrophages can target and activate the receptor protein C-C motif chemokine receptor 8 (CCR8) of HSCs, accelerating liver fibrosis progression by activating the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signalling pathway.www.researchsquare.com/article/rs-3723244/v1
CCR8 Signaling via CCL1 Regulates Responses of Intestinal IFN-γ ...
We newly identified CCR8 expression on a subgroup of intestinal ILCs producing IFN-γ and linked a functional CCL1/CCR8 axis with their abundance in the gut suggesting that this pathway axis …
Structural basis of antibody inhibition and chemokine ... - Nature
Dec 1, 2023 · Here, authors generated mAb1, an antagonist antibody against CCR8 and determined structures of CCR8 in complex with mAb1 or the agonist CCL1, providing insights …
The chemokine CCL1 triggers an AMFR-SPRY1 pathway …
Sep 14, 2021 · Chemokine (C-C motif) ligand 1 (CCL1) regulates tissue homeostasis through the recruitment of immune cells to sites of injury and …
- Author: Shan-shan Liu, Shan-shan Liu, Chang Liu, Xiao-xi Lv, Bing Cui, Jun Yan, Yun-xuan Li, Ke Li, Fang Hua...
- Publish Year: 2021
Structure/Function Relationships of CCR8 Agonists and …
The ligand of CCR8 is CCL1 (11, 12), which was identified originally as a polypeptide secreted by activated T-cells . In addition, CCL16 and CCL4 and …
- Author: James M. Fox, Pilar Najarro, Geoffrey L. Smith, Sofie Struyf, Paul Proost, James E. Pease
- Publish Year: 2006
Mar 23, 2021 · CC chemokine receptor 8 (CCR8) is a protein found mainly on the surface of a highly immunosuppressive subset of regulatory T cells (Tregs) within tumors. It is a regulator …
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The chemokine receptor CCR8 is not a high-affinity receptor for …
In one approach, we found that the previously-validated CCR8 agonist CCL1, was able to stimulate chemotaxis and endocytosis via CCR8 expressed in mouse pre-B cells but that …
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CCL1-CCR8 interactions: an axis mediating the recruitment of T …
Apr 15, 2005 · Taken together, these findings suggest that the axis CCL1-CCR8 links adaptive and innate immune functions that play a role in the initiation and amplification of atopic skin …
A CCL1/CCR8-dependent feed-forward mechanism drives ILC2 ... - PubMed
Dec 2, 2019 · However, we found that activated mouse and human ILC2s produce the CCR8 ligand CCL1 and are a major source of CCL1 in vivo. CCL1 signaling to ILC2s regulates their …
Earlier onset of chemotherapy-induced neuropathic pain in …
1 day ago · Moreover, activation of CCL1/CCR8 pathway through intrathecal injection of recombinant protein induced the pain behavior in naïve mice. On the basis of the previous …
CCR8 antagonist suppresses liver cancer progression via turning …
Apr 4, 2025 · In striking contrast, CCR8 has been shown to be critical for Treg immunosuppression. Stimulation of CCR8 + Tregs with CCL1 induces STAT3-dependent up …
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