Interferon regulatory factor (IRF) 7 was originally identified as master transcriptional factor that produced IFN-I and regulated innate immune response, subsequent studies have revealed that IRF7 performs a multifaceted and versatile functions in multiple biological processes.

Dec 20, 2002 · Here, we report that IRF7 is acetylated in vivo by the histone acetyltransferases p300/CBP-associated factor (PCAF) and GCN5. The single lysine residue target for acetylation, lysine 92, is located in the DNA-binding domain and is conserved throughout the entire IRF family.

Oct 9, 2024 · In U937 cells treated with PMA, both IRF1 and IRF2 undergo acetylation facilitated by p300 and p300/ CREB-binding protein (CBP)-associated factor (PCAF). 136 The p300-mediated IRF1...

Sep 1, 2006 · IRF7 is essential for the robust type I IFN gene induction that is elicited by ligation of TLR7 or TLR9, whereas IRF5 is required for the induction of pro-inflammatory cytokine genes....

Jan 8, 2019 · KHSV vIRF3 interacts with host IRF5 and IRF7, and vIRF3 can suppress IRF7 DNA binding activity to inhibit IFN-α production (113, 114). Furthermore, KHSV vIRF1 binds to p300 and interferes with CBP/p300-IRF3 complex formation as well as the HAT activity of p300, and thus prevents IRF3-mediated transcriptional activation (115).

Three family members, IRF3, IRF5, and IRF7, are critical to production of type I interferons downstream of pathogen recognition receptors that detect viral RNA and DNA. A fourth family member, IRF9, regulates interferon-driven gene expression.

May 2, 2003 · Interferon regulatory factor (IRF)-7 is activated in response to virus infection and stimulates the transcription of a set of cellular genes involved in host antiviral defense. The mechanism by which IRF-7 is activated and cooperates …

Apr 6, 2009 · IRF-3 expression activates predominantly IFN-A1 and IFN-B, while IRF-7 expression induces multiple IFN-A genes. IFN-A1 gene expression is dependent on three promoter proximal IRF elements (B, C, and D modules, located at positions −98 to −45 relative to the mRNA start site).

IRF1, IRF3, and IRF7 participate in the formation of a large protein complex called an IFN-β enhanceosome/DRAF1 that also includes nuclear factor-κB (NF-κB), activator protein 1 (AP1), and co-activators CREB binding protein (CBP)/p300 to activate transcription of the IFN-β …

Oct 15, 2014 · IFN regulatory factor 7 (IRF7) is a major regulator of type I (αβ) IFN secretion. A growing body of evidence shows that IRF7 is involved in a wide variety of pathologic conditions in addition to infections; however, the detailed mechanism of IRF7 transactivation remains elusive.