HDAC4 Governs a Transcriptional Program Essential for Synaptic ...
Nov 9, 2012 · We found that HDAC4, a histone deacetylase that shuttles between the nucleus and cytoplasm, controls a transcriptional program essential for synaptic plasticity and memory. …
- Author: Richard Sando, Natalia Gounko, Simon Pieraut, Lujian Liao, John Yates, Anton Maximov
- Publish Year: 2012
The Histone Deacetylase HDAC4 Regulates Long-Term Memory in
Dec 9, 2013 · Here, we investigate the role of HDAC4 in long-term memory formation in Drosophila. We show that overexpression of HDAC4 in the adult mushroom body, an …
- Author: Helen L. Fitzsimons, Silvia Schwartz, Fiona M. Given, Maxwell J. Scott
- DOI: 10.1371/journal.pone.0083903
- Publish Year: 2013
- Publication: PLoS One. 2013; 8(12): e83903.
Histone Deacetylase 4 (HDAC4): Mechanism of Regulations and …
HDAC4 can be phosphorylated by calcium/calmodulin-dependent protein kinase (CaMK), the extracellular signal-regulated kinases 1 and 2 (ERK1/2), protein kinase A (PKA) and glycogen …
- Studies of CA3 HDAC4
Class IIa HDACs regulate learning and memory through dynamic
Aug 2, 2019 · We found that, during learning, the cellular patterns of expression of early response genes (ERGs) are regulated by class IIa HDACs 4 and 5, transcriptional repressors that …
- Author: Yongchuan Zhu, Min Huang, Eric Bushong, Sebastien Phan, Marco Uytiepo, Elizabeth Beutter, Daniel Boe...
- Publish Year: 2019
The Class IIa histone deacetylase HDAC4 and neuronal
Sep 1, 2015 · Recent studies have revealed that Class IIa HDAC family member HDAC4 contributes essential functions to synaptic plasticity and memory as well as other neurological …
- Author: Helen L. Fitzsimons
- Publish Year: 2015
HDAC3 Is a Critical Negative Regulator of Long-Term …
We examined the role of HDAC3 in long-term memory using a combined genetic and pharmacologic approach. We used HDAC3–FLOX genetically modified mice in combination with adeno-associated virus-expressing Cre recombinase to …
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Histone deacetylase‐3 regulates the expression of the …
May 11, 2024 · HDAC3 inhibition has been shown to improve memory and reduce amyloid-β (Aβ) in Alzheimer's disease (AD) models, but the underlying mechanisms are unclear. We investigated the molecular effects of HDAC3 …
Cytoplasmic HDAC4 recovers synaptic function in the 3×Tg …
We investigated how the modulation of HDAC4 may contribute to counteracting AD pathogenesis. Using a cytoplasmic HDAC4 mutant (HDAC4 SD), we studied the recovery of synaptic function …
Nuclear Calcium Signaling Regulates Nuclear Export of a Subset of …
Mar 3, 2013 · Our HDAC4 loss-of-function and gain-of-function experiments support that concept that class IIa HDACs take part in the regulation of transcription following synaptic activity and …
Cytoplasmic HDAC4 recovers synaptic function in the …
Nov 4, 2022 · We investigated how the modulation of HDAC4 may contribute to counteracting AD pathogenesis. Using a cytoplasmic HDAC4 mutant (HDAC4 SD), we studied the recovery of synaptic function in hippocampal tissue and …
