Mar 10, 2020 · Here, we review the role of the Ca 2+-calcineurin-NFAT signaling pathway in health and diseases, focusing on the STIM and Orai1, and discuss the deregulated calcium …

The transcription factor NFAT has a crucial role in long-term Ca 2+ signaling. NFAT can induce gene expression by itself but can also cooperate with other transcription factors.

Ca 2+ /Calcineurin/NFAT signalling pathway regulates the growth and development of many types of cells, such as cardiomyocyte differentiation, angiogenesis, chondrogenesis, myogenesis, …

Jan 1, 2007 · In this chapter we will describe the Ca 2+ -calcineurin-NFAT pathway using the immune system, where it was first described and is best characterized, as a model. Ca 2+ is a …

Apr 19, 2002 · Probably no signaling molecule is so broad in its distribution yet so specific in its functions as Ca 2+. Regulated influx or release of Ca 2+ is critical to events as seemingly …

Repetitive or prolonged increase in intracellular Ca 2+ is required for the calcineurin-mediated dephosphorylation of the nuclear factor of an activated T cell (NFAT). Recent data indicate …

Jul 9, 2018 · Several studies suggest that the CN/NFAT pathway provides a putative link between Ca 2+ dysregulation, neuroinflammation and glutamate dysregulation in activated astrocytes …

Feb 7, 2012 · Four members of the NFAT family (NFAT1–4) are stimulated by a rise in cytoplasmic Ca 2+. In immune cells, activated NFAT regulates numerous inducible genes …

Mar 13, 2020 · Ca 2+ /nuclear factor of activated T-cells (Ca 2+ /NFAT) signaling pathway may play a crucial role in the pathogenesis of Kawasaki disease (KD). We investigated the poorly …

The signaling pathway linked with CaN and transcription factors like the nuclear factor of activated T cells (NFAT) is essential for skeletal muscle development and reprogramming of fast-twitch …