C5a is a protein fragment released from cleavage of complement component C5 by protease C5-convertase into C5a and C5b fragments.

It provides the United States Air Force (USAF) with a heavy intercontinental-range strategic airlift capability, one that can carry outsized and oversized loads, including all air-certifiable cargo. The Galaxy has many similarities to the smaller Lockheed C-141 Starlifter and the later Boeing C-17 Globemaster III.

Complement component 5 is involved in the complement system. It is cleaved into C5a and C5b: C5a plays an important role in chemotaxis. [6] C5b forms the first part of the complement membrane attack complex. Deficiency is thought to cause Leiner's disease.

Complement fragment (C)5a is a 74 residue pro-inflammatory polypeptide produced during activation of the complement cascade of serum proteins in response to foreign surfaces such as microorganisms and tissue damaged by physical or chemical injury.

C5a. The smaller fragment resulting from C5 cleavage is C5a (77-74 amino acids in length) which is a potent inflammatory molecule. C5a is molecularly characterized by having three disulfide bridges at its core with a disordered C-terminus (see figure 5).

Interaction of C5a with C5aR leads to many pleiotropic effects, including the release of cytokines and chemokines and recruitment of inflammatory cells. In certain circumstances, C5a–C5aR interactions can also result in pathophysiological changes as seen in sepsis, rheumatoid arthritis, asthma, acute lung injury and ischemia-reperfusion injury.

Activation of complement C5 generates the potent anaphylatoxin C5a and leads to pathogen lysis, inflammation and cell damage. The therapeutic significance of C5 inhibition is demonstrated by Eculizumab, one of the world’s most expensive drugs.

May 10, 2020 · C5 convertase, a serine protease, cleaves complement C5 into two different fragments, C5a and C5b. While C5b is crucially involved in the assembly of membrane attack complex (MAC), C5a activates two different seven transmembrane receptors, namely C5aR1 and …

A number of regulatory molecules help to control C5 mediated immune responses towards host cells, but in several major inflammatory conditions including sepsis and arthritis, C5a is believed to contribute significantly to disease etiology.

The 74 amino acid glycoprotein, complement component 5a (C5a), is a potent pro-inflammatory mediator cleaved enzymatically from its precursor, C5, upon activation of the complement cascade. C5a is quickly metabolised by carboxypeptidases, forming the less potent C5adesArg.