C57BL/6J mice are resistant to audiogenic seizures, have a relatively low bone density, and develop age related hearing loss. They are also susceptible to diet-induced obesity, type 2 diabetes, and atherosclerosis.

For over a century, the Jackson Laboratory has raised and distributed countless C57BL/6J (000664) mice. But has anyone wondered why this particular mouse, first bred in 1921 by Jackson Laboratory founder C.C. Little, has been so popular or acquired its name?

C57BL/6J is the most widely used inbred mouse strain and the first to have its genome sequenced. C57BL/6J mice are resistant to audiogenic seizures, have a relatively low bone density, and develop age related hearing loss.

Jan 3, 2019 · C57BL/6J mice are resistant to audiogenic seizures, have a relatively low bone density, and develop age related hearing loss. They are also susceptible to diet-induced obesity, type 2 diabetes, and atherosclerosis.

If you need to know whether your mouse has a C57BL/6J (B6J, 000664), C57BL/6N (B6N, 005304), or mixed B6J;B6N background, The Jackson Laboratory’s (JAX’s) new C57BL/6 Substrain Characterization Panel may be just the tool you need.

Mar 18, 2025 · View mouse strain C57BL/6J : mutations, QTL, phenotypes, diseases, and references.

Jun 22, 2016 · A mutation that causes spotty retinal degeneration, known as Crb1rd8 was discovered to be homozygous in all C57BL/6N related substrains, but is not present in the C57BL/6J substrain.

Susceptible to the development of atherosclerosis on a semi-synthetic high fat diet (1/9) (Nishina et al, 1993). Blood glucose levels and insulin insensitivity in crosses between diet-induced type II diabetes sensitive C57BL/6 and resistant A/J are genetically independent (Surwit et al 1991).

Jul 29, 2019 · “Eve” has been sequenced JAX researchers recently provided an update to the mouse reference genome that more accurately represents the genome of today’s C57BL/6J mice, using long read, short read, and optical mapping technologies to generate a de novo assembly of the C57BL/6J Eve genome.

033076 C57BL/6J-<i>Ptprc^em6Lutzy</i>/J JAXBoy (Ptprc^K302E) is a CRISPR-generated, coisogenic mutant of the <em>Ptprc</em> gene, expressing the Ptprc^a (CD45.1 or Ly5.1) rather than the Ptprc^b (CD45.2 or Ly5.2) allele normally expressed by C57BL/6J mice.