Complement component 4 (C4), in humans, is a protein involved in the intricate complement system, originating from the human leukocyte antigen (HLA) system. It serves a number of …

Oct 23, 2024 · Tests like the antinuclear antibody (ANA) and anti-double-stranded DNA (anti-dsDNA) are important tools for doctors to evaluate how active a person’s lupus is and to …

The DNA sequence encoding the Rg1 determinant is distinguishable by XcmI, and the LSP product associated with C4-Rg1 is thereby split into the 5′ fragment with 585 bp and the 3′ …

In human mitochondrial genetics, Haplogroup C is a human mitochondrial DNA (mtDNA) haplogroup. Haplogroup C is believed to have arisen in East Asia [4] some 24,000 years …

Nov 20, 2024 · From single-nucleus gene-expression and chromatin-accessibility atlases, we uncover DNA binding with one finger (DOF) motifs that define bundle-sheath identity in the …

To help understand the roles of C4 in the defense and pathogenesis of autoimmune and inflammatory diseases, we determined the bases of polymorphisms including the frequent …

C4 polymorphism can be defined at three levels: (i) at the genomic level regarding the gene structure and the number of C4 genes; (ii) at the DNA sequence level by determining …

Complement C4 is the only component coded for by two nearly identical isotypic genes, C4A and C4B. The C4 genes are located tandemly arranged each with a steroid 21-hydroxylase …

The goal of this protocol is to measure the principal features of C4 structural variation – including copy number of C4A, copy number of C4B, copy number of the long C4 genes (C4L) that …

These studies revealed that some complotypes were exclusively correlated with a particular C4 DNA variant, whereas others were not and could be subdivided according to which particular …