C3A [HepG2/C3A, derivative of Hep G2 (ATCC HB-8065)] is an epithelial-like cell isolated from the liver of a White, 15-year-old male patient with hepatocellular carcinoma. This cell line was deposited by Baylor College of Medicine and used in cancer, toxicology, and …

C3a is a 77 residue anaphylatoxin that binds to the C3a receptor (C3aR), a class A G protein-coupled receptor. It plays a large role in the immune response. C3a molecules induce responses through the GPCR C3a receptor.

Recently, the first clinical trials on Bioartificial Livers (BALs) loaded with a proliferative human hepatocyte cell source have started. There are two cell lines that are currently in an advanced state of BAL development; HepaRG and HepG2/C3A.

Although C3a binds to the anaphylatoxin receptor C3aR, C3b and its degradation products iC3b and C3dg interact with a variety of complement receptors (CR) to mediate immune adhesion, phagocytosis, and adaptive immune stimulation.

Apr 1, 2020 · C3A cells cultured with acute liver failure plasma showed mild inhibition of cell viabilities, reduction of albumin secretion, and increase of ammonia accumulation. Furthermore, CYP450 enzymes demonstrated various alterations on gene transcription, protein expression and enzyme activities.

Permanent human hepatocyte cell line and its use in a liver assist device (LAD). Mutations of the BRAF gene in human cancer. Signatures of mutation and selection in the cancer genome. A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.

The C3a receptor also known as complement component 3a receptor 1 (C3AR1) is a G protein-coupled receptor protein involved in the complement system. [ 5 ] [ 6 ] The receptor binds to complement component C3a , although there is limited evidence that this receptor also binds C4a in lesser mammals.

C3A cells cultured with acute liver failure plasma showed mild inhibition of cell viabilities, reduction of albumin secretion, and increase of ammonia accumulation. Furthermore, CYP450 enzymes demonstrated various alterations on gene transcription, protein expression and enzyme activities.

Neural crest cells are coattracted via the complement fragment C3a and its receptor C3aR, revealing an unexpected role of complement proteins in early vertebrate development. Loss of coattraction disrupts collective and coordinated movements of these cells.

Feb 10, 2021 · In this study, we developed an approach for genotoxicity testing with 21-day old spheroids formed from human hepatocellular carcinoma cells (HepG2/C3A) using the dynamic clinostat bioreactor system (CelVivo BAM/bioreactor) under controlled conditions.