C3a works with C5a to activate mast cells, recruit antibody, complement and phagocytic cells and increase fluid in the tissue, all of which contribute to the initiation of the adaptive immune …

C3a has a regulatory process and a structure homologous to complement component C5a, with which it shares 36% of its sequence identity. [1] C3a induces an immunological response …

The anaphylatoxins (AT) C3a, C5a and C5a-desArg are generally considered pro-inflammatory polypeptides generated after proteolytic cleavage of C3 and C5 in response to complement …

C3a and C5a, the small (approximately 10KDa) cleavage fragments released by complement activation, are potent mediators of inflammation. They are anaphylatoxins and act as cell …

Oct 17, 2023 · A series of cryo-EM structures offer insights into how anaphylatoxins C3a and C5a engage complement receptors, illustrating agonist binding modes, pathways of receptor …

May 11, 2023 · The complement receptors C3aR and C5aR1, whose signaling is selectively activated by anaphylatoxins C3a and C5a, are important regulators of both innate and …

This review provides a comprehensive overview of human C5a in the context of its structure and signaling under several pathophysiological conditions, including the current and future …

Recent insights into the role of complement anaphylatoxins C3a and C5a in cancer provide new opportunities for the development of innovative biomarkers and therapeutic strategies. These …

Dec 1, 2015 · Serum C3a and C5a concentrations were assayed as markers of upper and terminal Complement activation. Upper Complement activation peaked as 39% of C3 …

Mar 14, 2008 · Here, we demonstrate that locally produced C5a and C3a anaphylatoxins interacting with their G protein-coupled receptors (GPCRs), C5aR and C3aR, on APCs and T …