The C3a receptor also known as complement component 3a receptor 1 (C3AR1) is a G protein-coupled receptor protein involved in the complement system. [ 5 ] [ 6 ] The receptor binds to complement component C3a , although there is limited evidence that this receptor also binds C4a in lesser mammals.

May 11, 2023 · Dysregulations of C3aR and C5aR1 signaling lead to multiple inflammatory disorders, including sepsis, asthma and acute respiratory distress syndrome. The mechanism underlying endogenous...

The expression pattern of the human C3a receptor (C3aR) can provide important clues for the role of this anaphylatoxin in inflammation. There is strong evidence for C3aR expression on basophils, and eosinophils, but additionally, only on tumor cell lines of leukemic or hepatic origin.

C3a is a 77 residue anaphylatoxin that binds to the C3a receptor (C3aR), a class A G protein-coupled receptor. It plays a large role in the immune response. C3a molecules induce responses through the GPCR C3a receptor.

Jan 13, 2020 · Mechanically, C3a-C3aR signaling augments pro-metastatic cytokine secretion and extracellular matrix components expression of CAFs via the activation of PI3K-AKT signaling. Genetic or pharmacological blockade of C3aR signaling effectively inhibited lung metastasis of breast cancer in mouse models.

Mar 28, 2025 · C3AR1 (Complement C3a Receptor 1) is a Protein Coding gene. Diseases associated with C3AR1 include Atypical Hemolytic-Uremic Syndrome and Prostate Cancer . Among its related pathways are Class A/1 (Rhodopsin-like receptors) and Complement cascade .

To this end, the present study intended to explore the role of the C3a-C3aR and C5a-C5aR pathways in regulating RPE viability and inflammation during RD or RRDCD progression and investigate the underlying molecular mechanisms, with an …

C3aR (1 µM, sc-214644) and C5aR1 (1 µM, 65121-ANA) agonists potentiated glucose-induced insulin secretion from mouse and human islets, with similar stimulatory effects observed in islets incubated with 100 nM intact C3 and C5.

Aug 18, 2020 · The pathogenesis of some kidney diseases is closely associated with complement activation, where the C3a/C3a receptor (C3aR) might play a crucial role. C3a/C3aR has dual roles and may exert anti-inflammatory or pro-inflammatory effects depending on …

May 22, 2024 · In this review, we highlight our current understanding of one of the complement proteins, the complement C3a receptor (C3aR), in Alzheimer's disease. We will first describe its ligands and ligand-receptor interactions based on recent structural studies and its intracellular signaling pathways.