Intravitreal delivery of NMO-IgG causes primary retinal damage in …
Mar 7, 2025 · Ablating microglia significantly mitigated NMO-IgG-induced injury to RGCs. In vitro, NMO-IgG-treated MIO-M1 cells secreted higher levels of C3, enhancing the activation and …
Complement C3aR inactivation attenuates tau pathology and …
Dec 12, 2018 · We first treated C3aR-overexpressing BV2 cells with IL6 or C3 and found that C3 induced STAT3 phosphorylation (Figure 7F) and nuclear translocation (Figures 7G and …
TLQP-21 mediated activation of microglial BV2 cells
Apr 9, 2020 · TLQP-21 increases fAβ uptake by microglial BV2 cells via C3AR1-dependent mechanisms. TLQP-21 enhances the degradation of engulfed Aβ by stimulating a lysosomal …
Microglia aggravate white matter injury via C3/C3aR pathway after ...
Sep 1, 2024 · Activation of the C3-C3aR axis propels microglia towards a pro-inflammatory state after SAH. Inhibition of C3aR alleviates WMI and facilitates neurological function recovery after …
Functional profiling of the G protein-coupled receptor C3aR1 …
Jul 20, 2023 · Unlike in 3T3-L1 and BV2 cells, C3a 63-77 retained higher potency and efficacy in a wide dose-range than mTLQP-21 in the β-hexosaminidase secretion assay in LAD2 cells …
VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 ...
Jan 10, 2020 · We performed phagocytic/migration assays and RNA sequencing on BV2 microglial cells and primary microglia isolated from wild-type or C3aR1-null mice following …
The molecular identity of the TLQP-21 peptide receptor
Oct 9, 2021 · Two independent studies demonstrate that knocking down (KD) C3aR1 using siRNA in the BV2 microglial cell line or microglia from C3aR1-deficient mice , result in decreased …
Complement component 3 (C3) is regulated by TWIST1 and …
We showed that C3-induced reduction in E-cadherin expression in ovarian cancer cells was mediated by C3a and is Krüppel-like factor 5 (KLF5)-dependent. We investigated the …
VGF-derived peptide TLQP-21 modulates microglial function ... - PubMed
Jan 10, 2020 · Results: We demonstrate that TLQP-21 increases motility and phagocytic capacity in murine BV2 microglial cells, and in primary wild-type but not in C3aR1-null murine microglia, …
TLQP-21 mediated activation of microglial BV2 cells promotes
Apr 9, 2020 · TLQP-21 also improved microglial phagocytic activity and promoted fibrillar amyloid-β (fAβ) uptake by microglial BV2 cells via a C3AR1-dependent mechanism. Moreover, TLQP …