A spontaneous mutation in <em>Tlr4</em> occurred in C3H/HeJ at the lipopolysaccharide response locus (mutation in toll-like receptor 4 gene, <em>Tlr4^Lps-d</em>) making C3H/HeJ mice more resistant to endotoxin.

C3H/HeJ 小鼠通常称为 C3H 小鼠，作为一种常规品系广泛用于多种研究领域，包括癌症、传染病、感觉神经和心血管生物学研究。 C3H/HeJ 品系的脂多糖应答位点上发生 Tlr4 自发突变（toll 样受体 4 基因突变， Tlr4 Lps-d），使C3H/HeJ小鼠对内毒素具有更高的耐受性。 C3H/HeJ小鼠对革兰氏阴性菌（如肠沙门氏菌）高度易感。 杰克森实验室提供的C3H亚系为视网膜变性1基因 (Pde6b rd1) 突变的纯合小鼠，该突变会造成小鼠在离乳期失明。 重点提示: 此品系小鼠不携带小鼠乳腺 …

Aug 21, 2018 · As C3H/HeJ mice develop AA spontaneously in a low frequency, a novel animal model is needed to establish an AA-like condition faster and more conveniently. In this study, we present a novel...

C3H/He- Avy Congenic line developed by backcrossing the Avy to the C3H background. Has an exceptionally high mammary tumour incidence, virtually 100% at 7-8 months. The fostered substrain C3H- Avy f B has a 90% incidence of mammary tumours transmitted by either parent (Vlahakis et al., 1970., 1970). C3H.PRI- Flvr (formerly C3H.RV ) and C3H.M ...

Mar 18, 2025 · View mouse strain C3H/HeJ : mutations, QTL, phenotypes, diseases, and references.

C3H/HeJ mice are homozygous for retinal degeneration 1 mutation (Pde6b rd1), which causes blindness by weaning age. Typically unresponsive to lipopolysaccharide (LPS) due to a B-cell deficiency (Anderson and Ostermann, 1980).

Aug 6, 2024 · The C3H/HeJ mouse AA model, induced by either full-thickness skin grafts or cell transfer, has yielded a highly reproducible tool to work out the pathogenesis of this complicated and relatively common human disease.

Nov 24, 2018 · C3H/HeJ, also known as C3H and C3H Heston, is one of the most popular strains of inbred mouse models and is used in many areas of research. The C3H strain was created by Strong in 1920. A DBA mouse was crossed with a Bagg albino, selected for a high prevalence of mammary cancer.

A spontaneous mutation in Tlr4 occurred in C3H/HeJ at the lipopolysaccharide response locus (mutation in toll-like receptor 4 gene, Tlr4Lps-d) making C3H/HeJ mice more resistant to endotoxin. C3H/HeJ mice are highly susceptible to infection by Gram-negative bacteria such as Salmonella enterica.

• Retrieve SNPs for C3H/HeJ • Compare C3H/HeJ vs. one other strain • Strain type: Inbred • Vendor availability status: Readily Available