Jun 27, 2024 · The microglial-secreted complement protein C1q is internalized by neurons in an age-dependent manner, undergoes RNA-mediated interactions with neuronal …

Sep 25, 2024 · A recent study by Scott-Hewitt et al. demonstrates that microglia-derived C1q unexpectedly associates with the ribosomes of neurons in the aging murine brain, where it …

Sep 20, 2022 · Microglia and complement can mediate neurodegeneration in Alzheimer’s disease (AD). By integrative multi-omics analysis, here we show that astrocytic and microglial proteins …

In the central nervous system, C1q has diverse neuroprotective roles against pathogens and inflammation. Most of neurodegenerative diseases show region specific pathology feature in …

Using an unbiased screening strategy, we identify five novel transmembrane C1q signaling/receptor candidates in NSC, and define specific functions for the first of these, CD44, …

Oct 7, 2024 · A recent study published in Cell revealed that in the aging brain, the microglia-derived complement component C1q is internalized into neurons through endocytosis, …

Microglia added to C1q coated wells or fed apoptotic neurons or neuronal blebs coated with C1q suppressed the LPS-induced production of proinflammatory cytokines IL-1α, IL-1β, IL-6 and …

The expression of C1q, a recognition molecule of the complement system, is up-regulated following neuronal injury and is detected early in neurodegenerative disorders such as …

Mar 2, 2011 · In vitro, C1q, in the absence of other complement proteins, improves neuronal viability and neurite outgrowth and prevents β-amyloid-induced neuronal death, suggesting …

Aug 8, 2024 · Mice lacking C1q have age-specific alterations in neuronal protein synthesis in vivo and impaired fear memory extinction. Together, our findings reveal a biophysical property of …