Complement component 1q - Wikipedia
The complement component 1q (or simply C1q) is a protein complex involved in the complement system, which is part of the innate immune system. C1q together with C1r and C1s form the …
Complement component C1q is an immunological rheostat that regulates Fc:Fc
Jun 15, 2023 · Functionally, C1q-mediated Fc blockade limits the ability of NK cells to induce the upregulation of the cosignaling molecule, 4-1BB (CD137), and to mediate antibody-dependent …
IgG Fc domains that bind C1q but not effector Fcγ receptors …
Engineered crystallizable fragment (Fc) regions of antibody domains, which assume a unique and unprecedented asymmetric structure within the homodimeric Fc polypeptide, enable …
Fc-Galactosylation of Human Immunoglobulin Gamma Isotypes Improves C1q ...
Based on these data and our results, we suggest that Fc-galactosylation modulates Fc:Fc interactions for antigen-bound IgG, thereby improving binding of C1q and increasing the …
Functional and Structural Characterization of a Potent C1q …
The gC1q mediates the C1q interaction with numerous ligands including the Fc-region of antigen-bound IgG and IgM (5–7). Recognition by C1q leads to autoactivation of C1r which cleaves …
C1q: Its Functions within the Innate and Adaptive Immune Responses and ...
Jul 1, 2005 · C1q is the recognition component of the classical pathway. The best-known ligands for C1q are the Fc regions of aggregated immunoglobulin (Ig)G and IgM molecules in immune …
Fc-Fusion Drugs Have FcγR/C1q Binding and Signaling ... - PubMed
May 6, 2019 · Our comprehensive assessment demonstrates that (i) different Fc-fusion drugs have distinct C1q/FcγR binding and signaling properties, (ii) FcγR binding does not predict …
6FCZ: Model of gC1q-Fc complex based on 7A EM map - RCSB PDB
Dec 21, 2017 · Here, we present cryo-electron microscopy analyses of C1 bound to monoclonal antibodies in which we observed heterogeneous structures of single and clustered C1 …
Fc-Fusion Drugs Have FcγR/C1q Binding and Signaling ... - Springer
May 6, 2019 · We conducted a comparative study of FDA-approved Fc-fusion proteins for an assessment of Fc-FcγR and Fc-C1q interactions. We compiled a panel of five therapeutic Fc …
Structures of C1-IgG1 provide insights into how danger pattern
Feb 16, 2018 · The Fc-gC1q structure identified distinct C1q-binding sites on the two Fc-CH2 domains of an IgG1. The observed binding sites are corroborated with extensive mutagenesis, …
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