The study suggests that the C1q/C3-CR3 complement signaling pathway, which mediates abnormal microglial phagocytosis of synapses, presents a novel potential therapeutic target for …

Neurons were the major source of C1q mRNA. C1q protein and activated C3 localized at synapses within human leukocyte antigen-positive cell processes and lysosomes, suggesting …

Complement-mediated phagocytosis is accomplished by specific recognition of bound complement components using the corresponding complement receptors on the phagocytes. …

Sep 15, 2022 · The neuroprotection of minocycline, at least partly, is involved with the repression of the C1q/C3-CR3 signaling pathway. The complement C1q/C3-CR3 signaling is upregulated …

The complement component 1q (or simply C1q) is a protein complex involved in the complement system, which is part of the innate immune system. C1q together with C1r and C1s form the …

This group demonstrated a 2- and 5-fold upregulation of C3 and C1q mRNA, respectively, in the amyloid rich thalamic region of the brains from these transgenics (not in wild type animals).

Sep 20, 2022 · Microglia and complement can mediate neurodegeneration in Alzheimer’s disease (AD). By integrative multi-omics analysis, here we show that astrocytic and microglial proteins …

Upon antigen-antibody binding, C1q is activated and subsequently activates C1r and C1s, leading to the formation of C3 convertase C4b2a, C5 convertase C4b2a3b, and ultimately the …

Oct 1, 2008 · C1q binding to an antigen–antibody (Ag–Ab) complex gives rise to a C3 convertase activity in the resultant complex, which produces both C3a and C3b from C3 and in turn leads …

Sep 27, 2021 · Inhibiting the classical complement cascade by deleting the genes for C1q, C3 or CR3 rescues synapse loss and some cognitive impairment, including learning and memory …