The C1 complex (complement component 1, C1) is a protein complex involved in the complement system. It is the first component of the classical complement pathway and is composed of the …

The C1 complex is a giant proteolytic enzyme, which plays a leading role, because it is the first component in a proteolytic cascade initiated when complement is activated.

Oct 19, 2024 · Explore the intricate structure and activation of the C1 complex and its pivotal role in the immune response and related pathways. The C1 complex is a key component of the …

In this complex, C1q binds to diverse targets that activate the serine proteases and the proteases trigger effector reactions by cleaving specific substrate. Three physiological contexts are …

At molecular level, C1 is a complex composed of one C1q, two C1r, and two C1s subunits (C1qr 2 s 2). In the classical pathway, antibodies complexed with antigens bind C1q and change its …

Jul 1, 2004 · The combined use of a dissection strategy and of structural biology techniques has led to a refined, three-dimensional model of the C1 complex of complement, providing for the …

May 24, 2017 · Complement C1 is the defining component of the classical pathway. Within the C1qC1r₂C1s₂ complex, C1q functions as a molecular scaffold for …

C1r and C1s are the proteases responsible for the activation and proteolytic activity of the C1 complex of the classical complement pathway, respectively. They are assembled into a Ca …

Jun 16, 2023 · The classical pathway initiates when immune complexes bind to the C1 complex. The pathway continues in the following described way: The formation of antigen-antibody …

Jan 31, 2017 · The classical pathway of complement is activated upon binding of the 774-kDa C1 complex, consisting of the recognition molecule C1q and the tetrameric protease complex C1r …