A carbon–nitrogen bond is a covalent bond between carbon and nitrogen and is one of the most abundant bonds in organic chemistry and biochemistry. [1] Nitrogen has five valence electrons and in simple amines it is trivalent, with the two remaining electrons forming a lone pair.

Apr 25, 2022 · This Review examines the emerging area of heterogeneous electrocatalytic C–N bond formation using abundant starting materials, with the eventual goal of electrifying chemical manufacturing.

Mar 10, 2023 · The mechanism of polyketide chain release by C–N bond formation or thioester hydrolysis identified in this study indicates the catalytic versatility of the KS domain.

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Sep 17, 2022 · We discover that the *NH and *CO are the key precursors for C-N bonds formation at low overpotential, while at high overpotential the C-N coupling occurs between adsorbed *NH and solvated CO.

Thus, it is a challenge to develop alternative, milder and cheaper methodologies for the construction of C–N bonds. Herein, we have selected some prime literature reports that may serve this purpose.

Mar 20, 2024 · C-N bond formation is a key mechanistic step in N-integrated CO2 redn., so we focus on the possible pathways of C-N coupling starting from the CO2 redn. and nitrogenous small mols. redn. processes as well as the catalytic attributes that enable the C-N coupling.

Mar 23, 2018 · C−N bonds are widely found in natural products, medicinal molecules and multifunctional materials. In recent years, the construction of C−N bonds through a radical coupling reaction between carbon-centered radicals with nitrogen-centered radicals has emerged as a frontier area in organic chemistry.

Reductive amination is a powerful and reliable strategy for the formation of C–N bonds, and can avoid the problem of overalkylation that often accompanies direct alkylation of amines with alkyl halides.

Mar 1, 2024 · In this review, we will provide an overview of biocatalytic C–N bond-forming reactions that have emerged over the past five years, with a focus on enzymes that employ previously unknown mechanisms.