Protein c-Fos is a proto-oncogene that is the human homolog of the retroviral oncogene v-fos. [5] It is encoded in humans by the FOS gene. It was first discovered in rat fibroblasts as the transforming gene of the FBJ MSV (Finkel–Biskis–Jinkins murine osteogenic sarcoma virus) (Curran and Tech, 1982).

C-Fos is an immediate early gene that plays a significant role in memory formation, as indicated by research findings in neuroscience. AI generated definition based on: Learning and Memory: A Comprehensive Reference, 2008

The immediate early gene c-fos has long been known as a molecular marker of neural activity. The neuron’s activity is transformed into intracellular calcium influx through NMDA receptors and L-type voltage sensitive calcium channels.

We have thus examined the importance of c-Fos for neo-cortex development by comparing these two types of mice at different embryonic stages. c-fos −/− embryos present a ∼15% reduction in the thickness of the developing cortex as compared to wt controls.

Mar 4, 2002 · Our results suggest that c-fos is a genetic regulator for cellular mechanisms mediating neuronal excitability and survival.

The c-fos gene was first described as a proto-oncogene responsible for the induction of bone tumors. A few decades ago, activation of the protein product c-fos was reported in the brain after seizures and other noxious stimuli.

The presence of Fos, the protein product of the immediate-early gene c-fos, in a neuron has become a popular means to identify neurons that participate in a given function without losing the ability to know precisely where these neurons are.

Sep 1, 2014 · The mechanisms that co-ordinately activate lipid synthesis when high rates of membrane biogenesis are needed to support cell growth are largely unknown. c-Fos, a well known AP-1 transcription factor, has emerged as a unique protein with the capacity to associate to specific enzymes of the pathway of synthesis of phospholipids at the endoplasmic ...

Emerging evidence suggests that c-fos is essential in regulating neuronal cell survival versus death. Although c-fos is induced by neuronal activity, including kainic acid-induced seizures, whether and how c-fos is involved in excitotoxicity is still unknown.

This article summarizes the achievements that have been accumulated about the role of c-Fos as a transcription factor and as a functional marker of activated neurons. Since its discovery, more than a decade ago, as an inducible immediate-early …