Busulfan (Myleran, GlaxoSmithKline, Busulfex IV, Otsuka America Pharmaceutical, Inc.) is a chemotherapy drug in use since 1959. It is a cell cycle non-specific alkylating antineoplastic agent, in the class of alkyl sulfonates. Its chemical designation is 1,4-butanediol dimethanesulfonate.

Mar 10, 2024 · As an antineoplastic alkylating agent, busulfan is a crucial medication for treating these conditions, which warrants a review of its indications, mechanisms of action, and contraindications.

Busulfan is a chemotherapy medication that treats chronic myelogenous leukemia. This is a bone marrow cancer. It begins in your blood-forming cells and can spread to other areas of your body. This medication comes as a tablet that you can take by mouth with a glass of water as directed.

Apr 25, 2024 · Busulfan oral (taken by mouth) is used to treat the symptoms of chronic myelogenous leukemia (a type of blood cancer). Busulfan is not a cure for leukemia. Busulfan injection is used together with a medicine called cyclophosphamide, to prepare your body to receive a stem cell transplant from a donor's bone marrow.

Mar 1, 2025 · Busulfan injection is used in combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation for treatment of chronic myelogenous leukemia.

Busulfan is used treat a certain type of chronic myelogenous leukemia (CML; a type of cancer of the white blood cells). Busulfan is in a class of medications called alkylating agents. It works by slowing or stopping the growth of cancer cells in your body. How should this medicine be used? Busulfan comes as a tablet to take by mouth once a day.

Feb 21, 2014 · This page contains brief information about busulfan and a collection of links to more information about the use of this drug, research results, and ongoing clinical trials.

Nov 2, 2022 · Busulfan is a bifunctional alkylating agent in which two labile methanesulfonate groups are attached to opposite ends of a four-carbon alkyl chain. In aqueous media, busulfan hydrolyzes to release the methanesulfonate groups. This produces reactive carbonium ions that can alkylate DNA.

Busulfan is used to treat blood cancers. It is used in high doses together with other chemotherapy drugs before a stem cell transplant. It is also used in low doses to treat other types of blood cancers, such as essential thrombocythaemia and polycythaemia vera. It may sometimes be used to treat chronic myeloid leukaemia (CML).

Feb 17, 2020 · Busulfan is an alkylating agent which reacts with the N-7 position of guanosine and interferes with DNA replication and transcription of RNA. Busulfan has a more marked effect on myeloid cells than on lymphoid cells and is also very toxic to hematopoietic stem cells. Busulfan exhibits little immunosuppressive activity.